Results 41 to 50 of about 7,182,372 (402)

Utility of Bioluminescent Homogeneous Nucleotide Detection Assays in Measuring Activities of Nucleotide-Sugar Dependent Glycosyltransferases and Studying Their Inhibitors

Molecules, 2021
Traditional glycosyltransferase (GT) activity assays are not easily configured for rapid detection nor for high throughput screening because they rely on radioactive product isolation, the use of heterogeneous immunoassays or mass spectrometry.
Laurie Engel, Juliano Alves, Jacquelyn Hennek, Said A. Goueli, Hicham Zegzouti   +4 more
doaj   +1 more source

Caspase inhibitors [PDF]

Cell Death & Differentiation, 1999
Caspases are the key effector molecules of the physiological death process known as apoptosis, although some are involved in activation of cytokines, rather than cell death. They exist in most of our cells as inactive precursors (zymogens) that kill the cell once activated. Caspases can be controlled in two ways.
P G, Ekert, J, Silke, D L, Vaux
openaire   +2 more sources

2-Oxoester Phospholipase A₂ Inhibitors with Enhanced Metabolic Stability

Biomolecules, 2020
2-Oxoesters constitute an important class of potent and selective inhibitors of human cytosolic phospholipase A2 (GIVA cPLA2) combining an aromatic scaffold or a long aliphatic chain with a short aliphatic chain containing a free carboxylic acid ...
Giorgos S. Koutoulogenis, Maroula G. Kokotou, Daiki Hayashi, Varnavas D. Mouchlis, Edward A. Dennis, George Kokotos   +5 more
doaj   +1 more source

Molecular Determinant of DIDS Analogs Targeting RAD51 Activity

Molecules, 2021
RAD51 is the central protein in DNA repair by homologous recombination (HR), involved in several steps of this process. It is shown that overexpression of the RAD51 protein is correlated with increased survival of cancer cells to cancer treatments.
Denis Velic, Alexandre Demeyer, Thibaut Peterlini, Houda Benhelli-Mokrani, Monique Mathé-Allainmat, Jean-Yves Masson, Fabrice Fleury   +6 more
doaj   +1 more source

Selective serotonin reuptake inhibitors in the treatment of generalized anxiety disorder [PDF]

, 2002
Selective serotonin reuptake inhibitors have proven efficacy in the treatment of panic disorder, obsessive–compulsive disorder, post-traumatic stress disorder and social anxiety disorder.
Allgulander C, Andrew Mayers, Ansseau M, Aufdembrinke B. Abercarnil,, Ballenger JC, Barlow DH, Beekman AT, Carter RM, Chamey DS, Christel Buis, Connor KM, David Baldwin, Davidson JR, Durham RC, Durham RC, ECNP Consensus meeting, March, Fairbanks JM, Fawcett J, Feighner JP, Field MJ, Fontaine R, Gammans RE, Gelenberg AJ, Goa KL, Goldberg HL, Gould RA, Gould RA, Hedges DW, Hurst M, Keller MB, Pollack MET, Power KG, Rickels K, Rocca P, Rocca P, Sevy S, Sitsen JMA, Sramek JJ, Stahl S, Wardle J, Weizman R, Wittchen HU   +41 more
core   +1 more source

Anticancer Inhibitors

Molecules, 2022
Cancer is a multifactorial disorder caused by several aberrations in gene expression that generate a homeostatic imbalance between cell division and death [...]
Alessandra Ammazzalorso, Marialuigia Fantacuzzi   +1 more
openaire   +3 more sources

Development of a novel family of antifungal agents based on a quinone methide oxime framework

Scientific Reports
Given the widespread occurrence of fungal infections, the phenomenon of fungal drug resistance, and the limited number of systemic antimycotic therapies, novel chemicals should be developed to control pathogenic fungi.
Monika Janeczko, Maciej Masłyk, Oleg M. Demchuk, Antonina Kurowska-Okoń, Mateusz Kwaśnik, Kamila Górka, Aleksandra Martyna, Béatrice Foll-Josselin, Sandrine Ruchaud, Stéphane Bach, Przemysław Woliński, Radomir Jasiński, Barbara Mirosław, Małgorzata Sadczuk, Konrad Kubiński   +14 more
doaj   +1 more source

Emerging Role and Clinicopathological Significance of AEG-1 in Different Cancer Types: A Concise Review

Cells, 2021
Tumor breakthrough is driven by genetic or epigenetic variations which assist in initiation, migration, invasion and metastasis of tumors. Astrocyte elevated gene-1 (AEG-1) protein has risen recently as the crucial factor in malignancies and plays a ...
Sushmitha Sriramulu, Xiao-Feng Sun, Sarubala Malayaperumal, Harsha Ganesan, Hong Zhang, Murugesan Ramachandran, Antara Banerjee, Surajit Pathak   +7 more
doaj   +1 more source

Pazopanib Combined With Vincristine and Irinotecan in Relapsed Wilms Tumor: Encouraging Outcomes in a Heavily Pretreated Pediatric Cohort

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high‐risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi‐targeted tyrosine kinase ...
Maria Debora De Pasquale, Alessandro Crocoli, Giuseppe Maria Milano, Pierluigi Di Paolo, Francesca Diomedi Camassei, Ida Russo, Annalisa Serra   +6 more
wiley   +1 more source

Research towards selective inhibition of the CLK3 kinase

Beilstein Journal of Organic Chemistry
The cdc2-like kinases (CLKs), are a family of kinases that attracted recently the interest of scientists due to their significant biological roles, in particular in the regulation of the mRNA splicing process. Among the four isoforms of CLKs, CLK3 is the
Vinay Kumar Singh, Frédéric Justaud, Dabbugoddu Brahmaiah, Nangunoori Sampath Kumar, Blandine Baratte, Thomas Robert, Stéphane Bach, Chada Raji Reddy, Nicolas Levoin, René L. Grée   +9 more
doaj   +1 more source