Results 61 to 70 of about 2,714,339 (309)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Spontaneous bleeding in a patient with malignant lymphoma: A case of acquired hemophilia [PDF]

, 2000
Background: Acquired hemophilia is a rare condition which can be associated with lymphoproliferative disease. Case Report: Eleven yea rs after the diagnosis of immunocytoma had been made, a 72-year-old man developed a high-titer factor VIII inhibitor. At
Brack, N., Gesierich, Wolfgang, Pohlmann, H., Munker, Reinhold, Geiersberger, U., Hartenstein, R.   +5 more
core   +1 more source

DEVELOPMENT OF MEASURES TO ENSURE THE FAILURE-FREE DRILLING OF WELLS IN THE INTERVAL OF FROLOV SUITE ROCKS OCCURRENCE

Известия высших учебных заведений: Нефть и газ, 2015
The paper describes the analysis of study of hydration processes occurred in dense clay rocks stipulating the stability borehole walls at using various inhibitor solutions.
V. I. Rassadnikov, E. A. Usachev, M. V. Dvoinikov, T. V. Grosheva   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

The roles of p38mAPK and caspase-3 in dads-induced apoptosis in human HepG2 cells [PDF]

Archives of Biological Sciences, 2010
The roles of p38MAPK and caspase-3 in DADS-induced apoptosis in human HepG2 cells were investigated. After the human HepG2 cells were treated with DADS, the cell viability, apoptosis and the activity changes of p38MAPK and caspase-3 were measured.
Chunxiao Ji, Heng Ma, Ren Fenglian
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: Relationship to cystatins and the tumor suppressor TIG1 [PDF]

, 2005
Latexin, the only known mammalian carboxypeptidase inhibitor, has no detectable sequence similarity with plant and parasite inhibitors, but it is related to a human putative tumor suppressor protein, TIG1.
Listwan, P., Flanagan, Jack U., Flanagan, JU, Martin, Jennifer L, Listwan, P, Wells, Christine A, Kobe, Bostjan, Hume, DA, Cowieson, Nathan, Martin, Jennifer L., Hume, D A, Ravasi, T., Listwan, Pawel, Kellie, S, Kobe, B., Martin, Jennifer Louise, Cowieson, N. P., Martin, J. L., Huber, T, Huber, Thomas, Aagaard, A, Kobe, B, Flanagan, J. U., Ravasi, Timothy, Aagaard, A., A. Wells, Christine, Wells, C. A., Wells, Christine A., Aagaard, Anna, Wells, Christine, Flanagan, Jack U, Cowieson, N, Kellie, S., Huber, T. L., Hume, David A, Hume, D. A., Kellie, Stuart, Ravasi, T, Hume, David A., Wells, CA, Martin, JL   +40 more
core   +1 more source

The in vivo characterisation of a C-domain specific ACE inhibitor [PDF]

, 2013
Includes bibliographical references.The ACE protein is a zinc-dependent dipeptidyl carboxypeptidase comprised of two homologous domains termed the C- and N-domain.
Sharp, Sarah-Kate
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source