Results 81 to 90 of about 2,714,339 (309)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

The effect of certain N-tritylated phenylalanine conjugates of amino-adenosine-3',5'-cyclic monophosphate on Moloney murine leukaemia virus reverse transcriptase activity

South African Journal of Science, 2010
Moloney murine leukaemia virus (M-MuLV) is a member of the retrovirus family. Its cloned reverse transcriptase (RT), similarly to HIV type 1 reverse transcriptase (HIV-1 RT), exhibits DNA-polymerase and ribonuclease H (RNase H) activities capable of ...
Johann van Zyl, Mario Ariatti, Arthur Hawtrey   +2 more
doaj  

Investigation of Anticancer Properties of Newly Synthesized Pyridazine-Based Inhibitors in Mouse and Human Breast Cancer Cell Line

Biology
Background: Breast cancer is the most common cancer among women. Although doxorubicin (DOX) is widely used in its treatment, its dose-dependent toxicity and the development of drug resistance reduce its therapeutic efficacy. Therefore, this study aims to
Kübra Acikalin Coskun, Elif Cansu Abay, Mehmet Gumus, Ayşe Büşranur Çelik, Levent Gulum, Irfan Koca, Yusuf Tutar   +6 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The synergistic regulatory effect of PTP1B and PTK inhibitors on the development of Oedaleus decorus asiaticus Bei-Bienko

Journal of Integrative Agriculture
Tyrosine phosphorylation is crucial for controlling normal cell growth, survival, intercellular communication, gene transcription, immune responses, and other processes.
Shuang Li, Sibo Liu, Chaomin Xu, Shiqian Feng, Xiongbing Tu, Zehua Zhang   +5 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Multifaceted quorum-sensing inhibiting activity of 3-(Benzo[d][1,3]dioxol-4-yl)oxazolidin-2-one mitigates Pseudomonas aeruginosa virulence

Virulence
As antibiotic resistance escalates into a global health crisis, novel therapeutic approaches against infectious diseases are in urgent need. Pseudomonas aeruginosa, an adaptable opportunistic pathogen, poses substantial challenges in treating a range of ...
Yi Wu, Fulong Wen, Shiyi Gou, Qiman Ran, Yiwen Chu, Wenbo Ma, Kelei Zhao   +6 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Some Properties of Low-Molecular Trypsin Inhibitor from Cabbage Seed (Brassica oleracea) [PDF]

, 1993
P(論文)Some properties of the purifled low-molecular trypsin inhibitor (LMTI) from cabbage seed (Brassica oleracea) were investigated. The purified LMTl was homogeneous on the reverse phase HPLC.The molecular weight was about 5,000 and the isoelectoric ...
牛澤, 良美, ワタナベ, サトル, MORISUE, YUUKO, KITAO, SATOSHI, 11305, WATANABE, SATORU, 北尾, 悟, 森末, 裕子, 11289, 11300, 11288, キタオ, サトシ, 11302, 11301, 11304, 11303, 11290, 11292, 11291, ウメダ, ミチコ, 11294, 11293, 11296, 11295, 福澤, 美喜男, モリスエ, ユウコ, UMEDA, MICHIKO, USHIZAWA, YOSHIMI, ウシザワ, ヨシミ, 11298, 11297, 梅田, 美智子, フクザワ, ミキオ, 11299, 渡邉, 悟, FUKUZAWA, MIKIO   +35 more
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