Results 71 to 80 of about 2,714,339 (309)

ERK-Peptide-Inhibitor-Modified Ferritin Enhanced the Therapeutic Effects of Paclitaxel in Cancer Cells and Spheroids

, 2021
Rational design of a drug delivery system with enhanced therapeutic potency is critical for efficient tumor chemotherapy. Many protein-based drug delivery platforms have been designed to deliver drugs to target sites and improve the therapeutic efficacy.
Xun Li, Xun Li (182737), Yixin Dong (7459268), Yu Zhang (12946), Fei Wang, Yu Zhang, Yixin Dong, Yuanmeng Ma, Yuanmeng Ma (7969466), Fei Wang (19534)   +9 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Inhibitor-Dependent Usage of the S1 Specificity Pocket of ER Aminopeptidase 2

, 2022
Endoplasmic reticulum aminopeptidase 2 (ERAP2) is an intracellular enzyme involved in the processing of antigenic peptides intended for presentation by major histocompatibility complex class I (MHCI) molecules.
Efstratios Stratikos (340662), Efstratios Stratikos, Dimitris Georgiadis, Dimitris Georgiadis (2325748), Anastasia Mpakali, Petros Giastas (2942250), Anastasia Mpakali (3127524), Petros Giastas   +7 more
core   +1 more source

Dual MNK/VEGFR2 Inhibitor JDB153 Enhances Immunotherapeutic Efficiency and Chemosensitivity in Lung Cancer

MedComm
Lung cancer continues to be the primary cause of cancer‐related mortality worldwide, with non‐small cell lung cancer (NSCLC) being the predominant type.
Maosen Xu, Li Xu, Tao Zhang, Xue Li, Ziqi Zhang, Ruolan Xia, Ning Jiang, Li Yang, Xiawei Wei   +8 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Non-Steroidal Anti-Inflammatory Drugs Are Inhibitors of the Intestinal Proton-Coupled Amino Acid Transporter (PAT1): Ibuprofen and Diclofenac Are Non-Translocated Inhibitors

Pharmaceutics
Background/Objectives: The proton-coupled amino acid transporter (PAT1) is an intestinal absorptive solute carrier responsible for the oral bioavailability of some GABA-mimetic drug substances such as vigabatrin and gaboxadol.
Carsten Uhd Nielsen, Sebastian Jakobsen, Maria L. Pedersen   +2 more
doaj   +1 more source

Transcription and Translation Inhibitors in Cancer Treatment

Frontiers in Chemistry, 2020
Transcription and translation are fundamental cellular processes that govern the protein production of cells. These processes are generally up regulated in cancer cells, to maintain the enhanced metabolism and proliferative state of these cells.
Nihay Laham-Karam, Gaspar P. Pinto, Gaspar P. Pinto, Antti Poso, Antti Poso, Piia Kokkonen   +5 more
doaj   +1 more source

C5 inhibitors are not C5a inhibitors

Expert Review of Anti-infective Therapy, 2023
Endry H.T. Lim, Alexander P.J. Vlaar, Sanne de Bruin, Matthijs C. Brouwer, Diederik van de Beek   +4 more
openaire   +2 more sources