Results 221 to 230 of about 6,512,248 (384)

Immune-related adverse events of checkpoint inhibitors

Nature Reviews Disease Primers, 2020
M. Ramos-Casals, J. Brahmer, M. Callahan, A. Flores-Chávez, N. Keegan, M. Khamashta, O. Lambotte, X. Mariette, A. Prat, M. Suarez‐Almazor   +9 more
semanticscholar   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

A Promising Breakthrough for Triple-Negative Breast Cancer by Targeting the AKT and EZH2. [PDF]

MedComm (2020)
Liu Z, Li Y, Long X.
europepmc   +1 more source

ACTION OF INHIBITORS AT THE MYONEURAL JUNCTION [PDF]

, 1951
Leonard B. Kirschner, W. E. Stone
openalex   +1 more source

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

Electrochemical performance of a novel 1-(benzo[d]thiazol-2-yl)-3-methylguanidine as effective corrosion inhibitor for carbon steel in 1 M hydrochloric acid. [PDF]

Sci Rep
Abdel-Karim AM, Azzam RA, Shehata OE, Adly MA, El-Shamy OAA, El Mahdy GA.   +5 more
europepmc   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Targeting the Werner syndrome protein in microsatellite instability cancers: mechanisms and therapeutic potential. [PDF]

Clin Exp Med
Chen S, Wang Z, Cao Z, Xu M, Zhang Y.
europepmc   +1 more source

Identification of Novel Leishmania donovani Nucleoside Hydrolase Inhibitors from Banisteriopsis laevifolia Using Affinity Selection-Mass Spectrometry

ACS Omega
Pamella C. O. de Oliveira, Pedro R. C. Medeiros, Bruno C. B. Marques, Jorge L. S. Simão, Martin Albino, Vanessa G. P. Severino, Claudio Sangregorio, Luzineide W. Tinoco, Marcela C. de Moraes   +8 more
doaj   +1 more source

Paper Chromatographic Identification of Polypeptidic Gram Positive Inhibiting Antibiotics [PDF]

, 1956
Neva Snell, K. Ijichi, J. C. Lewis
openalex   +1 more source