Results 231 to 240 of about 3,954,159 (357)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Molecularly Targeted Therapies in Oncology: Mechanisms, Resistance, and Combination Strategies. [PDF]

Molecules
Giercuszkiewicz-Haśnik K, Morak-Młodawska B, Jeleń M.   +2 more
europepmc   +1 more source

Substituted lin-benzopurines as inhibitors of tRNA-guanine transglycosylase: modulation of enzyme dimerization and replacement of water clusters

, 2013
Luzi Jakob Barandun
openalex   +1 more source

Decision letter for "Association of SGLT2 inhibitors with outcomes in Type 2 diabetes with reduced and preserved left ventricular ejection fraction — Analysis from the CVD‐REAL 2 Study"

, 2020

openalex   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Efficacy and Safety of Carbonic Anhydrase Inhibitors in the Management of Central Serous Chorioretinopathy. [PDF]

J Vitreoretin Dis
Abu Serhan H, Ashraf S, Saeed H, Safiullah M, Ul Haq MZ, Shaukat A, Ansari MA, Shah MSU, Ahmed A.   +8 more
europepmc   +1 more source

Author response for "Fournier's gangrene and SGLT‐2 inhibitors: A Meta‐Analysis of randomized controlled trials"

, 2019
Giovanni Antonio Silverii, Ilaria Dicembrini, Matteo Monami, Edoardo Mannucci   +3 more
openalex   +1 more source

Mitogen-Activated Protein Kinase Inhibitor

, 2020
National Cancer Institute
openalex   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Disrupting the KRAS-SOS1 protein-protein interaction: mechanistic rationale for pan-KRAS pathway suppression and combination therapy. [PDF]

Front Chem
Kamel EM, Khadrawy SM, Ali MAM, Abukhadra MR, Yassin NYS, Alkhedhairi S, Aba Alkhayl FF, Lamsabhi AM.   +7 more
europepmc   +1 more source