Results 241 to 250 of about 2,171,591 (317)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

SGLT2 Inhibitors in Alzheimer's Disease: Biochemical Insights and Therapeutic Potential. [PDF]

Int J Mol Sci
Mazzeo P, Vietri M, Tecce N, Delizia A, Remondelli V, Ciaglia T, Di Dio A, Corletti L, Pizzuti CG, Pepe G, Stabile E, Correale M, Campiglia P, Miranda MR, Tecce MF, Vestuto V.   +15 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Tolerability of SGLT2 inhibitors in patients with Fabry disease: An observational study. [PDF]

Am Heart J Plus
Mattig I, Zirkelbach B, Bonnekoh C, Stangl K, Hindricks G, Knebel F, Canaan-Kühl S, Spethmann S.   +7 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Ras-MAPK inhibition induces AXIN1 loss in colorectal cancer by mTOR associated suppression of protein synthesis. [PDF]

Cell Commun Signal
Venkatachalam N, Wang L, Muthukumarana N, Ihnatko R, Krijgsveld J, Skabkina O, Leipertz A, Chen Y, Sui P, Zheng Q, Tong P, Liu X, Descot A, Schewe M, Diamante G, Jackstadt R, Brochhausen C, Betge J, Boonekamp K, Boutros M, Stoecklin G, Ebert M, Schott J, Zhan T.   +23 more
europepmc   +1 more source

Radiosensitisation of Head and Neck Cancer Cells to Protons of Increasing LET Through Targeting DNA Double Strand Break Repair. [PDF]

Cells
Dufficy ER, Goula A, Melia E, Bellamy A, Parsons JL.   +4 more
europepmc   +1 more source

TEAD inhibitors synergize with MEK, SHP2 and mTOR inhibitors in NF1 and NF2 cell lines. [PDF]

MicroPubl Biol
Yang Y, Gurunathan S, Schechter S, Field J.   +3 more
europepmc   +1 more source

Correction for Zhang et al., Conserved use of tetraspanin CD9 as an entry receptor by rhabdoviruses spanning multiple genera. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source