Results 251 to 260 of about 3,954,159 (357)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Peer Review #1 of "Monensin may inhibit melanoma by regulating the selection between differentiation and stemness of melanoma stem cells (v0.1)"

, 2019
Haoran Xin, Jie Li, Hao Zhang, Yuhong Li, Shuo Zeng, Zhi Wang, Zhihui Zhang, Fang Deng, V Amann, E Ramelyte, S Thurneysen, R Pitocco, N Bentele-Jaberg, S Goldinger, R Dummer, J Mangana, X Chen, J Cui, Z Yan, H Zhang, X Chen, N Wang, P Shah, F Deng, C Zhao, N Geng, M Li, S Denduluri, R Haydon, H Luu, R Reid, T He, D Cummins, J Cummins, H Pantle, M Silverman, A Leonard, Chanmugam, Y Deng, J Zhang, Z Wang, Z Yan, M Qiao, J Ye, Q Wei, J Wang, X Wang, L Zhao, S Lu, S Tang, M Mohammed, H Liu, J Fan, F Zhang, Y Zou, J Liao, H Qi, R Haydon, H Luu, T He, L Tang, M Griffin, D Scotto, D Josephs, S Mele, S Crescioli, H Bax, G Pellizzari, M Wynne, M Nakamura, R Hoffmann, K Ilieva, A Cheung, J Spicer, S Papa, K Lacy, Karagiannis Sn, H Guo, K Yang, F Deng, Y Xing, Y Li, X Lian, Yang, A Gupta, S Love, A Schuh, M Shanyinde, J Larkin, R Plummer, P Nathan, S Danson, C Ottensmeier, P Lorigan, L Collins, A Wise, R Asher, R Lisle, Middleton Mr, K Ketola   +99 more
openalex   +2 more sources

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Attempts to Achieve Targeted Covalent Inhibition of Hsp90β. [PDF]

Chem Biol Drug Des
D'Amico T, Reynolds TS, Serwetnyk MA, Blagg BSJ.   +3 more
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

A degrader of HER2 and EGFR abolishes p95HER2 and shows robust antitumor efficacy in HER2-positive breast cancer. [PDF]

Sci Rep
Yang L, Bhattacharya A, Li Y, Peterson D, Zhang Y.   +4 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Ribociclib is not a substrate or inhibitor of Oatp1b-mediated uptake in vivo. [PDF]

Cancer Chemother Pharmacol
Drabison T, Ahmed EA, Colasanti N, Weber RH, Sparreboom A, Eisenmann ED.   +5 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Efficacy of PD-1/PD-L1 inhibitors combined with multi-targeted anti-angiogenic TKIs in advanced or metastatic NSCLC: A meta-analysis based on RCTs. [PDF]

Front Oncol
Tang Z, Zhang X, Sun Z, Zhang S, Feng X, Chen Y, Xu H.   +6 more
europepmc   +1 more source