Results 251 to 260 of about 6,512,999 (388)

Efficacy and safety of first-line PD-1/PD-L1 inhibitors combined with or without anti-angiogenesis therapy for extensive-stage small-cell lung cancer: a network meta-analysis. [PDF]

Ther Adv Med Oncol
Zhou L, Li Y, Wang L, Chen K, Zhou S, Chen Y, Sun J, Tong Y, Fan Y.   +8 more
europepmc   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Correction: METTL3-induced lncRNA GBAP1 promotes hepatocellular carcinoma progression by activating BMP/SMAD pathway. [PDF]

Biol Direct
Liu R, Yin G, Tuo H, Guo Y, Zhu Y, Zhang L, Yang W, Liu Q, Wang Y.   +8 more
europepmc   +1 more source

AN INHIBITOR OF VIRAL ACTIVITY APPEARING IN INFECTED CELL CULTURES

, 1959
Monto Ho, John F. Enders
openalex   +1 more source

Efficacy of acetylcholinesterase inhibitors in Alzheimer's disease

Neuropharmacology, 2020
G. Marucci, M. Buccioni, D. D. Ben, C. Lambertucci, R. Volpini, F. Amenta   +5 more
semanticscholar   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

The Role of Axl Inhibition and Immune Checkpoint Blockade in Non-small Cell Lung Cancer: Current Understanding and Treatment Strategies. [PDF]

Cancer Diagn Progn
Kim TW, Kim SH, DO HJ, Suh YA, Jeong D, Lee C.   +5 more
europepmc   +1 more source

A PROTEOLYTIC INHIBITOR WITH ANTICOAGULANT ACTIVITY SEPARATED FROM HUMAN URINE AND PLASMA

, 1955
N. Raphael Shulman
openalex   +1 more source

The effect of metabolic inhibitors on respiration and glycolysis in electrically stimulated cerebral-cortex slices [PDF]

, 1953
P. J. Heald
openalex   +1 more source

Acquired Resistance to Immune Checkpoint Inhibitors.

Cancer Cell, 2020
A. Schoenfeld, M. Hellmann
semanticscholar   +1 more source