Results 251 to 260 of about 6,774,149 (386)

Development of a Rapid In Vitro Screening Assay Using Metabolic Inhibitors to Detect Highly Selective Anticancer Agents

, 2021
Felagot A. Abebe, Megan D. Hopkins, Suraj N. Vodnala, Robert J. Sheaff, Angus A. Lamar   +4 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Cutaneous Lymphoma Associated with JAK Inhibitors: A Pharmacovigilance Analysis of the FAERS Database and Literature Review. [PDF]

Acta Derm Venereol
Lu L, Feng J, He H, Peng Y, Zhang S, Yang L, Liu Y, Wang T.   +7 more
europepmc   +1 more source

Calprotectin Expression Inhibits Bacterial Binding to Mucosal Epithelial Cells

, 2001
Kanokwan Nisapakultorn, Karen F. Ross, Mark C. Herzberg   +2 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Identification and biological evaluation of benzimidazole-based compounds as novel TGFβR1 inhibitors. [PDF]

J Enzyme Inhib Med Chem
Tseng HJ, Wu YW, Chen YL, Lin TE, Fang-Chin YT, Wu YL, Sung TY, Yen SC, Hsieh JH, Hsu KC, Pan SL.   +10 more
europepmc   +1 more source

Quaternized Chitosan Inhibits icaA Transcription and Biofilm Formation by Staphylococcus on a Titanium Surface

, 2010
Zhaoxiang Peng, Bing Tu, Yang Shen, Lin Du, Ling Wang, Shengrong Guo, Tingting Tang   +6 more
openalex   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Comparing Different As-Treated Approaches: A Methodological Study Using Real-World Data on Psoriasis Treatments. [PDF]

Pharmacoepidemiol Drug Saf
Kim S, Jensen A, Egeberg A, Stensballe LG.   +3 more
europepmc   +1 more source

Synthesis of Omeprazole Analogues and Evaluation of These as Potential Inhibitors of the Multidrug Efflux Pump NorA ofStaphylococcus aureus

, 2006
Céline Vidaillac, Jean Guillon, Corinne Arpin, Isabelle Forfar, Boubakar B. Ba, Jean Grellet, Stéphane Moreau, Daniel‐Henri Caignard, Christian Jarry, Claudine Quentin   +9 more
openalex   +1 more source