Results 261 to 270 of about 6,512,999 (388)

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Angiotensin II Type 1 Receptor Blocker Usage Prevents Oxidative Stress and Muscle Dysfunction in HIV. [PDF]

Fundam Clin Pharmacol
Deminice R, Cella PS, Borsari AL, Padilha CS, de Oliveira VHF.   +4 more
europepmc   +1 more source

THE MECHANISM BY WHICH GLYCERALDEHYDE INHIBITS GLYCOLYSIS

, 1950
Henry A. Lardy, Virgil D. Wiebelhaus, Kingsley M. Mann   +2 more
openalex   +1 more source

ACCUMULATION OF ACETYLCHOLINE IN BRAIN AND BLOOD OF ANIMALS POISONED WITH CHOLINESTERASE INHIBITORS [PDF]

, 1952
W. C. Stewart
openalex   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Research progress on the effect of neutrophil elastase and its inhibitors in respiratory diseases. [PDF]

J Int Med Res
Liang CC, Zhao J, Zhang YQ, Chen J, Wang Y.   +4 more
europepmc   +1 more source

On the chemical reactions occurring between certain substances which inhibit bacterial growth and the constituents of bacteriological media [PDF]

, 1942
A. E. Oxford
openalex   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Recent advances in focal adhesion kinase (FAK)-targeting antitumor agents. [PDF]

RSC Adv
Zhu SK, Wu Q, Liu GX, Geng AQ, Wang PA.
europepmc   +1 more source

High Molecular Weight Enzyme Inhibitors. III. Polyestradiol Phosphate, a Long-acting Estrogen. [PDF]

, 1958
O. Fernö, H. Fex, Björn Högberg, T. Linderot, S. Veige, E. Diczfalusy   +5 more
openalex   +1 more source