Results 31 to 40 of about 5,057,415 (322)
Novel structural features of CDK inhibition revealed by an ab initio computational method combined with dynamic simulations [PDF]
Journal of Medicinal Chemistry 49, 5141-5153 (2006), 2008 The rational development of specific inhibitors for the ~500 protein kinases encoded in the human genome is impeded by a poor understanding of the structural basis for the activity and selectivity of small molecules that compete for ATP binding. Combining classical dynamic simulations with a novel ab initio computational approach linear-scalable to ...
arxiv +1 more source
New Advances in Targeted Therapy of HER2-Negative Breast Cancer
Frontiers in Oncology, 2022 Breast cancer has an extremely high incidence in women, and its morbidity and mortality rank first among female tumors. With the increasing development of molecular biology and genomics, molecular targeted therapy has become one of the most active areas ...
Junsha An +4 more
doaj +1 more source
Immune checkpoint inhibitors: recent progress and potential biomarkers
Experimental and Molecular Medicine, 2018 Cancer growth and progression are associated with immune suppression. Cancer cells have the ability to activate different immune checkpoint pathways that harbor immunosuppressive functions. Monoclonal antibodies that target immune checkpoints provided an
Pramod Darvin +3 more
semanticscholar +1 more source
Cell Research, 2020 A new coronavirus SARS-CoV-2, also called novel coronavirus 2019 (2019-nCoV), started to circulate among humans around December 2019, and it is now widespread as a global pandemic.
Chunlong Ma +10 more
semanticscholar +1 more source
Revista Brasileira de Ginecologia e Obstetrícia, 2008 OBJETIVO: avaliar um novo esquema terapêutico de emprego do atosibano quanto ao efeito tocolítico, eficácia e efeitos colaterais maternos e fetais.
Fábio Roberto Cabar +3 more
doaj +1 more source
The Functions of BET Proteins in Gene Transcription of Biology and Diseases
Frontiers in Molecular Biosciences, 2021 The BET (bromodomain and extra-terminal domain) family proteins, consisting of BRD2, BRD3, BRD4, and testis-specific BRDT, are widely acknowledged as major transcriptional regulators in biology.
Ka Lung Cheung +2 more
doaj +1 more source
A class of carbonic anhydrase I – selective activators
Journal of Enzyme Inhibition and Medicinal Chemistry, 2017 A series of ureido and bis-ureido derivatives were prepared by reacting histamine with alkyl/aryl-isocyanates or di-isocyanates. The obtained derivatives were assayed as activators of the enzyme carbonic anhydrase (CA, EC 4.2.1.1), due to the fact that ...
Erol Licsandru +4 more
doaj +1 more source
Discovery of small molecule inhibitors of Leishmania braziliensis Hsp90 chaperone
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Leishmaniasis is a neglected disease caused by the protozoa Leishmania ssp. Environmental differences found by the parasites in the vector and the host are translated into cellular stress, leading to the production of heat shock proteins (Hsp). These are
Fernanda A. H. Batista +7 more
doaj +1 more source
Dual Effects of Cyclooxygenase Inhibitors in Combination With CD19.CAR-T Cell Immunotherapy
Frontiers in Immunology, 2021 Chimeric antigen receptor T (CAR-T) cells targeting CD19 came into clinical practice for the treatment of B cell lymphoma in 2018. However, patients being treated for B cell lymphoma often suffer from comorbidities such as chronic pain, cardiovascular ...
Mingya Yang +24 more
doaj +1 more source
Inhibitors of mammalian G1 cyclin-dependent kinases.
Genes & Development, 1995 Biologic machines need brakes, and the nature and fidelity of their operation cannot be unraveled without some prior understanding of how accelerators work. The discoveD] of mammalian G1 cyclins just 4 years ago and the identification of their associated
C. Sherr, James M. Roberts
semanticscholar +1 more source