Results 41 to 50 of about 3,716,801 (336)
New Advances in Targeted Therapy of HER2-Negative Breast Cancer
Frontiers in Oncology, 2022 Breast cancer has an extremely high incidence in women, and its morbidity and mortality rank first among female tumors. With the increasing development of molecular biology and genomics, molecular targeted therapy has become one of the most active areas ...
Junsha An +4 more
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Acta Dermato Venereologica, 2018 Abnormally high production of melanin or melanogenesis in skin melanocytes results in hyperpigmentation disorders, such as melasma, senile lentigines or freckles. These hyperpigmentary skin disorders can significantly impact an individual's appearance, and may cause emotional and psychological distress and reduced quality of life.
Kumari, Sulekha +3 more
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Effect of Inhibitors and Admixed Chloride on Electrochemical Corrosion Behavior of Mild Steel Reinforcement in Concrete in seawater [PDF]
, 1992 Electrochemical potential monitoring experiments have been · fc:' performed on the mild steel rebars embedded in concrete !· admixed with different inhibitors and sodium chloride salt and e~posed to sea water environment. The electrode potential of j ·
Loto, C. A.
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Revista Brasileira de Ginecologia e Obstetrícia, 2008 OBJETIVO: avaliar um novo esquema terapêutico de emprego do atosibano quanto ao efeito tocolítico, eficácia e efeitos colaterais maternos e fetais.
Fábio Roberto Cabar +3 more
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The Functions of BET Proteins in Gene Transcription of Biology and Diseases
Frontiers in Molecular Biosciences, 2021 The BET (bromodomain and extra-terminal domain) family proteins, consisting of BRD2, BRD3, BRD4, and testis-specific BRDT, are widely acknowledged as major transcriptional regulators in biology.
Ka Lung Cheung +2 more
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A class of carbonic anhydrase I – selective activators
Journal of Enzyme Inhibition and Medicinal Chemistry, 2017 A series of ureido and bis-ureido derivatives were prepared by reacting histamine with alkyl/aryl-isocyanates or di-isocyanates. The obtained derivatives were assayed as activators of the enzyme carbonic anhydrase (CA, EC 4.2.1.1), due to the fact that ...
Erol Licsandru +4 more
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Discovery of small molecule inhibitors of Leishmania braziliensis Hsp90 chaperone
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Leishmaniasis is a neglected disease caused by the protozoa Leishmania ssp. Environmental differences found by the parasites in the vector and the host are translated into cellular stress, leading to the production of heat shock proteins (Hsp). These are
Fernanda A. H. Batista +7 more
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Dual Effects of Cyclooxygenase Inhibitors in Combination With CD19.CAR-T Cell Immunotherapy
Frontiers in Immunology, 2021 Chimeric antigen receptor T (CAR-T) cells targeting CD19 came into clinical practice for the treatment of B cell lymphoma in 2018. However, patients being treated for B cell lymphoma often suffer from comorbidities such as chronic pain, cardiovascular ...
Mingya Yang +24 more
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Inhibitors of Pyruvate Carboxylase [PDF]
, 2010 This review aims to discuss the varied types of inhibitors of biotin-dependent carboxylases, with an emphasis on the inhibitors of pyruvate carboxylase.
Attwood, Paul V. +2 more
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ChemistryOpen, 2019 Tau protein is a natively unfolded protein whose primary role is to participate in axonal transport closely associated with microtubules. Neurodegenerative disorders including Alzheimer's disease and Tauopathies involved tau protein that is found ...
Dr. Carlos Areche +7 more
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