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Activating and inhibitory functions of DAP12

Nature Reviews Immunology, 2007
When associated with different receptors, the signalling adaptor DAP12 has been shown to both potentiate and attenuate the activation of leukocytes. But how can a protein with a single signalling motif elicit qualitatively different cellular responses?
Isaiah R, Turnbull, Marco, Colonna
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Viral Inhibitory Activity of Polyvinylpyrrolidone

Nature, 1966
POLYVINYLPYRROLIDONE (PVP), a commercial organic chemical which bears a close physical resemblance to plasma protein, has been found to have a strong inhibitory action on viruses without appearing significantly toxic to animals. Cells pretreated with PVP showed resistance to infection with herpes simplex and vaccinia viruses in vitro.
B S, Michaels   +3 more
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The inhibitory activity of ω-methylpantothenol

Archives of Biochemistry and Biophysics, 1954
Abstract The inhibitory activity toward four lactic acid bacteria of pantothenol and ω-methylpantothenic acid has been compared to that of the hybrid analog, ω-methylpantothenol. The activity of the latter was found to be intermediate between the activities of the parent substances.
W, DRELL, M S, DUNN
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PAF inhibitory activity of diketopiperazines: Structure‐activity relationships

Lipids, 1991
AbstractFR900452, a natural product isolated from the culture broth ofStreptomyces phaeofaciens No. 7739, was found to inhibit PAF‐induced rabbit platelet aggregation with an IC50 of 3.7×10−7M. FR900452, 1‐methyl‐3‐[1‐[5‐methylthiomethyl‐6‐oxo‐3‐(2‐oxo‐3‐cyclopenten‐1‐ylidene)‐2‐piperazinyl]ethyl]‐2‐indoline, has an oxocylopentylidene group ...
N, Shimazaki   +5 more
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Synthesis and iNOS inhibitory activities of thioflavones

Archives of Pharmacal Research, 2005
A number of thioflavones has been synthesized and evaluated for their iNOS inhibitory activities. Thiowogonin (6) was obtained from naturally occurring chrysin in 5 steps. Other thioflavones were prepared from the corresponding flavones in a single step by the reaction with Lawesson's reagent. The biological activities of thioflavones were not enhanced
Tran Thanh, Dao   +2 more
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