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Activating and Inhibitory FcγRs in Autoimmune Disorders
Springer Seminars in Immunopathology, 2006Autoimmune disorders are characterized by the destruction of self-tissues by the immune system. Multiple checkpoints are in place to prevent autoreactivity under normal circumstances. Coexpression of activating and inhibitory Fc receptors (FcR) represents such a checkpoint by establishing a threshold for immune cell activation. In many human autoimmune
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Inhibitory activity of guanidine on poliovirus proteins
Life Sciences, 1971Abstract Previous researches (1,2) have shown that guanidine inhibits virus RNA replication in poliovirus infected cells, but has a modest effect on virus protein synthesis. However, guanidine prevents the appearance in infected cultures of two virus protein dependent “products”, i.e., RNA polymerase activity and cytopathic effect (3,4).
P. L. Colla +4 more
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The regulation of lymphocyte activation by inhibitory receptors
Current Opinion in Immunology, 2004The ability of activating immune recognition receptors on lymphocytes to regulate cellular activation and function can be profoundly altered by co-stimulation with inhibitory receptors. Inhibitory receptors, such as the MHC-recognizing inhibitory receptors expressed on NK cells and subpopulations of activated T cells, can fully block the generation of ...
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Inhibitory Action of Glucides on Trypsin Activity
Nature, 1966GLUCIDES, usually unimportant reagents, can affect the activity of enzymes. Farber and Wynne1 have reported that some monosaccharides have marked inhibitory effect on the activity of pancreatic proteinase. A similar observation has been made by Whitaker et al.2 with α-amylase.
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Lipoxygenase inhibitory activity of alkyl protocatechuates
Food Chemistry, 2014Alkyl 3,4-dihydroxybenzoates (protocatechuates) inhibited linoleic acid peroxidation catalyzed by soybean lipoxygenase-1 (EC 1.13.11.12, Type 1). Their inhibitory activities displayed a parabolic function of their lipophilicity and maximized with alkyl chain lengths of between C11 and C14.
Tae Joung, Ha +2 more
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Inhibitory activity of intestinal intraepithelial lymphocytes*
Surgery, 1995Intestinal intraepithelial lymphocytes (iIEL) are the first line of lymphoid cells exposed to orally absorbed foreign antigen. Because of this unique position, we hypothesized that the iIEL down-regulates the immune response to foreign antigen to prevent broad sensitization.One-way mixed lymphocyte cultures (MLCs) were performed with Brown Norway (BN ...
D H, Teitelbaum +3 more
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The inhibitory effect of tris on the activity of cholinesterases
Biochimica et Biophysica Acta (BBA) - Enzymology, 1967Abstract 1. I. In order to obtain a clearer picture of the effect of Tris on cholinesterases we undertook experiments using acetylcholinaterase (acetylcholine acetyl-hydrolase, E.C. 3.1.1.7) and cholinesterase (acylcholine acyl-hydrolase, EC 3.1.1.8). 2. 2.
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Novel peptides with tyrosinase inhibitory activity
Peptides, 2007Tyrosinase inhibition by peptides may find its application in food, cosmetics or medicine. In order to identify novel tyrosinase inhibitory peptides, protein-based peptide libraries made by SPOT synthesis were used to screen for peptides that show direct interaction with tyrosinase.
Schurink, M. +3 more
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Amplification of the inhibitory activity of miglitol by monofluorination
Bioorganic & Medicinal Chemistry Letters, 2009Selective monofluorination of the alpha-glycosidase inhibitor and antidiabetic agent Miglitol at position C2 creates an competitive inhibitor of five times higher activity than the parent compound. Its screening against a panel of human cell lines showed a low cytotoxicity therefore making this compound an interesting candidate for further clinical ...
Erik, Prell, René, Csuk
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Tumor-Inhibitory Activity of Pyrrolizidine Alkaloids
Journal of Pharmaceutical Sciences, 1968Eighteen pyrrolizidine alkaloids and several derivatives have been examined for tumor-inhibitory properties. Of these, 10 compounds show significant activity against one or more test tumors. Heliotrine, lasiocarpine, monocrotaline, spectabiline, and senecionine are highly active against the Walker 256 (intramuscular) system.
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