Results 261 to 270 of about 7,577,140 (312)

Inhibitory Effects of Lodoxamide on Eosinophil Activation

International Archives of Allergy and Immunology, 1998
Recent reports describe the beneficial use of lodoxamide, an anti-allergic compound, for the treatment of asthma and allergic conjunctivitis. Lodoxamide is known as a mast cell stabilizer, however, the association of a significant clinical improvement with a specific decrease in eosinophil infiltrate suggested possible direct effects of lodoxamide on ...
M, Capron, S, Loiseau, J P, Papin, S, Robertson, A, Capron   +4 more
openaire   +2 more sources

Trypsin inhibitory activity of Lawsonia inermis

Fitoterapia, 2002
The ethanolic extract of Lawsonia inermis leaves and lawsone tested for trypsin inhibitory activity showed an IC(50) value of 64.87 and 48.6 microg/ml, respectively.
S, Yogisha, D S, Samiulla, D, Prashanth, R, Padmaja, A, Amit   +4 more
openaire   +2 more sources

Medicinal plants with acetylcholinesterase inhibitory activity

Reviews in the Neurosciences, 2018
AbstractAlzheimer’s disease, a progressive neurodegenerative disease, is characterised by hypofunction of acetylcholine (ACh) neurotransmitter in the distinct region of brain. Acetylcholinesterase (AChE) is an enzyme that metabolises the ACh at synaptic cleft resulting in Alzheimer’s disease.
Sita Sharan, Patel, Ramsaneh, Raghuwanshi, Misha, Masood, Ashish, Acharya, Surendra Kumar, Jain   +4 more
openaire   +2 more sources

Lipoxygenase Inhibitory Activity of Octyl Gallate

Journal of Agricultural and Food Chemistry, 2004
Octyl gallate inhibited soybean lipoxygenase-1 (EC 1.13.11.12, type I) with an IC(50) of 1.3 microM. The inhibition of the enzyme by octyl gallate is a slow and reversible reaction without residual activity. The inhibition kinetics analyzed by Lineweaver-Burk plots indicates that octyl gallate is a competitive inhibitor, and the inhibition constant, K ...
Tae Joung, Ha, Ken-ichi, Nihei, Isao, Kubo   +2 more
openaire   +2 more sources

Activity‐dependent Refinement of Inhibitory Connections

European Journal of Neuroscience, 1993
AbstractSeveral lines of evidence suggest that excitatory synaptic transmission contributes to the maturation of precise neuronal connections. In the present study we determined whether the specific innervation pattern of single inhibitory arborizations was dependent upon neuronal activity during development.
D H, Sanes, C, Takács
openaire   +2 more sources

Inhibitory activities of bipyrazoles: a patent review

Expert Opinion on Therapeutic Patents, 2021
Bipyrazole is constituted from two pyrazole units either in their fully aromatic or partially hydrogenated forms. Pyrazoles are widely available in pharmaceutical and agrochemical products. Some pyrazoles are essential parts of commercial drugs in the market.
Ashraf A. Abbas, Magda H. Abdellattif, Kamal M. Dawood   +2 more
openaire   +2 more sources

The effect of agar on the inhibitory activity of phenols

Antonie van Leeuwenhoek, 1963
Nineteen phenols were tested for their effectiveness in inhibiting the growth ofStaphylococcus aureus in both broth and agar media. The presence of agar in the test medium interfered with the action of eight of the compounds tested.
J G, SANDS, L A, GOERS, E O, BENNETT
openaire   +2 more sources

Pituitary Gonadotropin Inhibitory Activity of Danazol

Fertility and Sterility, 1974
A steroid danazol (17-alpha-Pregn-4-en-20-yno(23-d)-isoxazol-17-ol) possesses a marked separation of pituitary gonadotropin inhibitory activity from overt sex hormonal activities. The effect of danazol on fertility in the rat was determined. Danazol produced a dose-related decrease in the weights of ventral prostate seminal vesicles and testes of ...
G O, Potts, A L, Beyler, H P, Schane
openaire   +2 more sources

Prediction of inhibitory activities of Hsp90 inhibitors

Bioorganic & Medicinal Chemistry, 2012
Here, we report on the development of a novel methodology to aid in design of Hsp90 inhibitors, using molecular docking combined with artificial neural network (ANN) modelling. Inhibitors are first docked into the ATPase site of the Human Hsp90α crystal structures and the thermodynamic properties of the complexes together with various physical-chemical
Swuec, Paolo, Barlow, David J.
openaire   +3 more sources

Lipoxygenase Inhibitory Activity of Anacardic Acids

Journal of Agricultural and Food Chemistry, 2005
6[8'(Z)-pentadecenyl]salicylic acid, otherwise known as anacardic acid (C15:1), inhibited the linoleic acid peroxidation catalyzed by soybean lipoxygenase-1 (EC 1.13.11.12, type 1) with an IC50 of 6.8 microM. The inhibition of the enzyme by anacardic acid (C15:1) is a slow and reversible reaction without residual activity.
Tae Joung, Ha, Isao, Kubo
openaire   +2 more sources