Results 261 to 270 of about 742,740 (307)

Cyclooxygenase Inhibitory and Antioxidant Compounds from Crabapple Fruits

Journal of Agricultural and Food Chemistry, 2003
Crabapple trees belong to the Malus genus (Rosaceae) and bear fruits that are sparingly consumed and used in the preparation of fruit beverages. Cyclooxygenase (COX) enzyme inhibitory and antioxidant bioassay-guided fractionation of the aqueous and methanol extracts of Malus x kornicensis and Malus x Indian Summer yielded (+)-catechin (1 ...
Navindra P, Seeram, Robert H, Cichewicz, Amitabh, Chandra, Muraleedharan G, Nair   +3 more
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CHEMICAL COMPOUNDS WITH INHIBITORY EFFECT IN HYPERTHYROIDISM

Journal of the American Medical Association, 1945
To the Editor:— Occasionally, discoveries are made in apparently unrelated fields in medicine which under closer examinations can be brought under a common denominator. While a chief resident at the Montefiore hospital, New York, I was investigating a possible influence of thiouracil on cancer of the thyroid gland.
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Antihypertensive compounds with potent protein kinases inhibitory activity

Life Sciences, 1989
A new indorocarbazole antibiotic SF2370 has been found in the culture broth of Actinomadura sp.; it has also been found to have the activities of antihypertension and diuresis. Derivatives of SF2370, NA0344, NA0345 and NA0346, when injected (0.1-1 mg/kg i.v.) significantly lowered the blood pressure of anesthetized normotensive rats and showed a long ...
M, Hachisu, T, Hiranuma, M, Koyama, M, Sezaki   +3 more
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Cyclooxygenase inhibitory compounds from Gymnosporia heterophylla aerial parts

Fitoterapia, 2017
Gymnosporia heterophylla (Celastraceae) is an African medicinal plants used to treat painful and inflammatory diseases with partial scientific validation. Solvent extractions followed by repeated chromatographic purification of the G. heterophylla aerial parts led to the isolation of one new β-dihydroagarofuran sesquiterpene alkaloid (1), and two ...
Charles O. Ochieng, Sylvia A. Opiyo, Edward W. Mureka, Ismail O. Ishola   +3 more
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AUTOTAXIN INHIBITORY COMPOUNDS

2016
The present invention relates to compounds of formula I, wherein A1, A2, A3, R1, R2, R3, R4, R5, R6, L, Ar and Q are each as defined herein. The compounds of the present invention are inhibitors of autotaxin (ATX) enzyme activity. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions ...
Stockley, Martin, Lee, MacDonald, Ellen, Catherine, Pritom,, Shah, Jordan,, Allan, Hitchin,, James, Hamilton,, Niall   +5 more
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PARG INHIBITORY COMPOUNDS

2016
The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity: wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions
Jordan, Allan, Waszkowycz,, Bohdan, Hutton, Colin, Waddell, Ian, Hitchin, James, Smith, Kate, Hamilton, Niall, Mcgonagle, Alison   +7 more
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Induction of sporulation by inhibitory purines and related compounds

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1978
Sporulation of Bacillus subtilis can be induced, in the presence of excess ammonia, glucose and phosphate, by many purine derivatives under conditions of partial growth inhibition. Some of the compounds are known inhibitors of purine nucleotide synthesis. For most compounds the effect is counteracted by adenine and guanine. Partial growth inhibition by
J E, Heinze, T, Mitani, K E, Rich, E, Freese   +3 more
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Tyrosinase Inhibitory Activity of the Olive Oil Flavor Compounds

Journal of Agricultural and Food Chemistry, 1999
A series of alpha,beta-unsaturated aldehydes, otherwise known as (2E)-alkenals, characterized from the olive Olea europaea L. (Oleaceae) oil flavor was found to inhibit the oxidation of L-3, 4-dihydroxyphenylalanine (L-DOPA) catalyzed by mushroom tyrosinase, and the inhibition kinetics analyzed by a Lineweaver-Burk plot found that they are ...
I, Kubo, I, Kinst-Hori
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Free Radical Inhibitory Effect of Some Anticancer Compounds

Science, 1971
Conventional tests for polymerization initiated by free radicals indicate that alkylating agents vary in free radical inhibitory activity from negligible to moderately strong; antimetabolites from negligible to weak; hormones, steroids, and phenolics from very weak to very strong; and antibiotics from moderate to very strong.
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Anticonvulsant and Growth Inhibitory Effects of Some Organophosphorus Compounds*

Journal of the American Pharmaceutical Association (Scientific ed.), 1953
A series of organophosphates, structurally ghosphoryl analogs of phenylurethane, have een tested for anticonvulsant and growth inhibitory effects. The effects were expected from structural considerations.
D, RAMASWAMI, E R, KIRCH
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