Results 91 to 100 of about 7,131,135 (287)

Major Constituents of Resin Exhibit Cyclooxygenase Enzyme Inhibition and Antiproliferative Activity

Natural Product Communications, 2013
Aromatic gum from Boswellia carteri (olibanum oleogum) has long been used in Egyptian traditional medicine. Cyclooxygenase-1 (COX-1) enzyme inhibitory assay guided purification of the extracts of this resin resulted in five bioactive compounds, 3α- O ...
Sami I. Ali, Chuan-Rui Zhang, Amal A. Mohamed, Farouk K. EL-Baz, Ahmad K. Hegazy, Maimona A. Kord, Muraleedharan G. Nair   +6 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The study of antibacterial activity of non-polar extract of Malva silvestris L., using well diffusion and tube dilution method. [PDF]

Āsīb/shināsī-i Darmāngāhī-i Dāmpizishkī, 2015
Nowadays, due to the resistance of bacteria to antibiotics and their side effects, much attention is paid to the antibacterial properties of medicinal plants. Malva sylvestis L. plays an important role in traditional medicine and herbal medicine industry.
akbar hassanpour, solmaz zakhireh, amirreza ebadi   +2 more
doaj  

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Anti–Herpes Simplex Virus Type-1 Activity and Phenolic Content of Crude Ethanol Extract and Four Corresponding Fractions of L Acorn

Journal of Evidence-Based Complementary & Alternative Medicine, 2017
This research was aimed to evaluate anti–herpes simplex virus type-1 (anti-HSV-1) activity of crude ethanol extract and 4 corresponding fractions of Quercus brantii acorn in vitro.
Ali Karimi PhD, Mahmoud Rafieian-Kopaei PhD, Mohammad-Taghi Moradi PhD student, Somayeh Alidadi BSc   +3 more
doaj   +1 more source

Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC).

, 2015
n = 3**Effected by solvent concentrationMinimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC).
Glen E. Kellogg (204170), Yan Zhang (8098), Fadi El-rami (823332), Ping Xu (122619), Victoria N. Stone (823331), Xiuchun Ge (288402), Weihau Chen (823333), Hardik I. Parikh (380208)   +7 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

2021 global food 50/50 report: A review of the gender- and equity-related policies and practices of 52 organizations active in the global food system

This inaugural 2021 Global Food 50/50 Report, a joint initiative of Global Health 50/50 and IFPRI, reviews the gender- and equity-related policies and practices of 52 global food system organizations in the food system from the public, private, and not ...
Global Health 50/50, Njuki, Jemimah, Tanaka, Sonja, International Food Policy Research Institute   +3 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source