Results 101 to 110 of about 1,997,109 (329)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Major Constituents of Resin Exhibit Cyclooxygenase Enzyme Inhibition and Antiproliferative Activity

Natural Product Communications, 2013
Aromatic gum from Boswellia carteri (olibanum oleogum) has long been used in Egyptian traditional medicine. Cyclooxygenase-1 (COX-1) enzyme inhibitory assay guided purification of the extracts of this resin resulted in five bioactive compounds, 3α- O ...
Sami I. Ali, Chuan-Rui Zhang, Amal A. Mohamed, Farouk K. EL-Baz, Ahmad K. Hegazy, Maimona A. Kord, Muraleedharan G. Nair   +6 more
doaj   +1 more source

Nanobody mediated inhibition of attachment of F18 fimbriae expressing Escherichia coli [PDF]

, 2014
Post-weaning diarrhea and edema disease caused by F18 fimbriated E. coli are important diseases in newly weaned piglets and lead to severe production losses in farming industry.
Coddens, Annelies, Cox, Eric, De Greve, Henri, De Kerpel, Maia, Moonens, Kristof, Pardon, Els, Remaut, Han   +6 more
core   +4 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Evaluation of the effects of diethyl ether and methanol extracts of carpet anemone (Sarcophyton spp.) and starfish (Pentaceraster spp.) on E. coli and Bacillus subtilis bacteria

‬‭Majallah-i ̒Ilmī-i Shīlāt-i Īrān, 2019
Marine environment is the main source of natural bioactive products whose chemical-structural properties are not similar with other natural products of plants and other inland organisms. The present study was carried out to evaluate antibiotic properties
M. Mansurlakuraj; K. Rezaei Tavabe; A.R. Mirvaghefi; M. Nazemi; M.A. Nematollahi; M. Jahandideh
doaj  

A novel chemotherapeutic sensitivity-testing system based on collagen gel droplet embedded 3D–culture methods for hepatocellular carcinoma

BMC Cancer, 2017
Background Patients suffering from advanced stage hepatocellular carcinoma (HCC) often exhibit a poor prognosis or dismal clinical outcomes due to ineffective chemotherapy or a multi-drug resistance (MDR) process.
Jun Hou, Zhixian Hong, Fan Feng, Yantao Chai, Yunkai Zhang, Qiyu Jiang, Yan Hu, Shunquan Wu, Yingsong Wu, Xunian Gao, Qiong Chen, Yong Wan, Jingfeng Bi, Zheng Zhang   +13 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Antiviral potential of sugarcane bagasse-derived carbon quantum dots against SARS-CoV-2, and herpes simplex virus-1

Discover Applied Sciences
Viral diseases pose a serious global threat due to their ability to spread quickly and mutate. The ongoing SARS-CoV-2 pandemic exemplifies this challenge, as effective treatments and vaccines are still under development.
Hebat-Allah S. Tohamy, Mohamed El-Sakhawy, Sahar Abd Al-Daim, Ahmed N. El Taweel   +3 more
doaj   +1 more source

Anti–Herpes Simplex Virus Type-1 Activity and Phenolic Content of Crude Ethanol Extract and Four Corresponding Fractions of L Acorn

Journal of Evidence-Based Complementary & Alternative Medicine, 2017
This research was aimed to evaluate anti–herpes simplex virus type-1 (anti-HSV-1) activity of crude ethanol extract and 4 corresponding fractions of Quercus brantii acorn in vitro.
Ali Karimi PhD, Mahmoud Rafieian-Kopaei PhD, Mohammad-Taghi Moradi PhD student, Somayeh Alidadi BSc   +3 more
doaj   +1 more source

Comparative Analysis of the Inhibitory Efficacy of 50% and 80% Concentrations of Rambutan Seed Extract (Nephelium lappaceum L.) on the Growth of Candida albicans

Indonesian Journal of Rheumatology
Introduction. Denture stomatitis is a prevalent issue among those who wear dentures, and it is caused by Candida albicans. Ketoconazole, an azole antifungal medication, is commonly employed to treat denture stomatitis. However, it is important to note that the usage of this agent might lead to hepatotoxicity and the development of resistance.
Wijaya, Cindy Denhara, Daryono, Rasyika Adani   +2 more
openaire   +2 more sources