Results 81 to 90 of about 7,131,135 (287)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Inhibitory concentration 50% (IC₅₀) values in μg/mL with standard error for two cyathostomin lines treated with either pyrantel or Cry5B.

, 2018
Inhibitory concentration 50% (IC50) values in μg/mL with standard error for two cyathostomin lines treated with either pyrantel or Cry5B.
Raffi V. Aroian (103098), Thanh-Thanh Nguyen (5236655), Melanie Miller (1579858), Yan Hu (30839), Bo Zhang (6559), Martin K. Nielsen (5236652)   +5 more
core   +1 more source

Functional characterization of the Plasmodium falciparum and P-berghei homologues of macrophage migration inhibitory factor [PDF]

, 2007
Macrophage migration inhibitory factor (MIF) is a mammalian cytokine that participates in innate and adaptive immune responses. Homologues of mammalian MIF have been discovered in parasite species infecting mammalian hosts (nematodes and malaria ...
Sarah E. Reece, Pain, Arnab, Robert Kleemann, Kooistra, Teake, Augustijn, Kevin D., Reece, Sarah E., Thompson, Joanne, Siebum, Arjan H. G., Joanne Thompson, Kevin D. Augustijn, Waters, Andrew P., Arjan H. G. Siebum, Kleemann, Robert, Arnab Pain, Janse, Chris J., Chris J. Janse, Teake Kooistra, Carina E. Crawford, Crawford, Carina E., Andrew P Waters   +19 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Evaluation of the effects of diethyl ether and methanol extracts of carpet anemone (Sarcophyton spp.) and starfish (Pentaceraster spp.) on E. coli and Bacillus subtilis bacteria

‬‭Majallah-i ̒Ilmī-i Shīlāt-i Īrān, 2019
Marine environment is the main source of natural bioactive products whose chemical-structural properties are not similar with other natural products of plants and other inland organisms. The present study was carried out to evaluate antibiotic properties
M. Mansurlakuraj; K. Rezaei Tavabe; A.R. Mirvaghefi; M. Nazemi; M.A. Nematollahi; M. Jahandideh
doaj  

Summary of Drug Titrations Showing 50% Inhibitory Concentration, IC₅₀, in Breast Cancer Cell Lines Treated with Paclitaxel and Analogs.

, 2015
The IC50 values are given in nM. Values and errors (SE) shown are representative of n = 3 independent experiments.* P < 0.05 determined for IC50 for each analog relative to paclitaxel.Summary of Drug Titrations Showing 50% Inhibitory Concentration, IC50,
Richard F. Ludueña (751489), Sambasivarao Damaraju (102523), Ahmed T. Ayoub (747972), Carol E. Cass (102519), Mariusz Klobukowski (747973), Jack A. Tuszynski (160860), Marc St. George (318231), Philip Winter (291799), Asok Banerjee (751487), Cassandra D. M. Churchill (751488)   +9 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Antiviral potential of sugarcane bagasse-derived carbon quantum dots against SARS-CoV-2, and herpes simplex virus-1

Discover Applied Sciences
Viral diseases pose a serious global threat due to their ability to spread quickly and mutate. The ongoing SARS-CoV-2 pandemic exemplifies this challenge, as effective treatments and vaccines are still under development.
Hebat-Allah S. Tohamy, Mohamed El-Sakhawy, Sahar Abd Al-Daim, Ahmed N. El Taweel   +3 more
doaj   +1 more source