Results 81 to 90 of about 753,617 (295)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Half maximal inhibitory concentration (IC₅₀) values of various fractions of E. longifolia root methanolic extract on K-562 cell line.

, 2014
Half maximal inhibitory concentration (IC50) values of various fractions of E. longifolia root methanolic extract on K-562 cell line.
Shah Kamal Khan Jamal Din (485574), Narazah Mohd Yusoff (506418), Aman Shah Abdul Majid (506419), Omar Saeed Ali Al-Salahi (506413), Dan Ji (485571), Amin Malik Shah Abdul Majid (506414), Wan Zaidah Abdullah (506416), Abdelhamid Zaki (506417), Chan Kit-Lam (506415)   +8 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Half-maximal inhibitory concentration (IC₅₀) values of TCD and colchicine, indicating their cytotoxic effects in hepatocellular carcinoma (HCC) cell lines.

, 2015
Half-maximal inhibitory concentration (IC50) values of TCD and colchicine, indicating their cytotoxic effects in hepatocellular carcinoma (HCC) cell lines.
Yu-Jia Chang (143398), Chun-Te Ho (479321), Po-Li Wei (292225), Tsan-Zon Liu (479323), Jun-Jen Liu (508011), Li-Xi Yang (793873)   +5 more
core   +1 more source

Determination of Half-Maximal Inhibitory Concentration (IC₅₀) of Drugs Using Contrast Surface Plasmon Imaging on Gold-Coated Periodic Nanowires

Analytical Chemistry
The half-maximal inhibitory concentration (IC50) is a critical pharmacological parameter used to quantify a drug's potency in inhibiting biological functions. In this study, we present a novel strategy to evaluate the cytotoxicity of anticancer drugs on CL1-0 and A549 lung cancer cells, Huh-7 liver cancer cells, and MCF-7 breast cancer cells using ...
Hsien-San Hou, Kuang-Li Lee, Ting-Jui Tu, Ji-Yen Cheng, Pei-Kuen Wei   +4 more
openaire   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Mean inhibitory concentration (IC) 50 values (μg/mL) for triplicate assays with pseudoviruses (psVs) and the geometric mean (GM) as indicated.

, 2016
Mean inhibitory concentration (IC) 50 values (μg/mL) for triplicate assays with pseudoviruses (psVs) and the geometric mean (GM) as indicated.
Monick Lindenmeyer Guimarães (53176), Valdiléa Gonçalves Veloso dos Santos (3391013), Karine Venegas Macieira (3391007), Dalziza Victalina de Almeida (3391004), Beatriz Gilda Jegerhorn Grinsztejn (3391010)   +4 more
core   +1 more source

Compounds from Extracts with Toxicity against the Fish Pathogenic Bacterium

Natural Product Communications, 2016
The pond-raised channel catfish (Ictalurus punctatus ) industry in the United States of America can incur losses of over a $100 million annually due to bacterial diseases including columnaris disease caused by Flavobacterium columnare.
Kevin K. Schrader, Charles L. Cantrell, Jacob O. Midiwo, Ilias Muhammad   +3 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Determination of Minimum Inhibitory Concentration (MIC) of Hygromycin B in CHO cells: The minimum inhibitory concentration determination

, 2019
Chinese hamster ovary (CHO) cells are considered as the most commonly used host for industrial manufacturing of therapeutic proteins. The aim of this study was to evaluate the minimum inhibitory concentration (MIC) of hygromycin B in both CHO-DG44 and ...
Tabarzad, Maryam, Naddafi, Fatemeh, H. Shirazi, Farshad   +2 more
core   +1 more source