Results 71 to 80 of about 753,617 (295)

Identification of responders/non-responders to 5-fluorouracil based on individual 50% inhibitory area under the concentration curve of 5-fluorouracil obtained with collagen gel droplet-embedded culture-drug sensitivity test in colorectal cancer

Oncology Letters, 2011
We previously reported the 5-fluorouracil (5-FU) sensitivity of cancer cells obtained from colorectal cancer (CRC) patients using the collagen gel droplet-embedded culture-drug sensitivity test (CD-DST). Multiple drug concentrations and contact durations, and the area under the concentration curve (AUC) and growth inhibition rate (IR) were combined ...
Takumi, Ochiai, Kazuhiko, Nishimura, Tomoo, Watanabe, Masayuki, Kitajima, Akinori, Nakatani, Takashi, Marusasa, Tadasuke, Hashiguchi, Takayuki, Uchida, Naoki, Sakuyama, Tsuyoshi, Sato, Kennji, Kishine, Shunji, Futagawa, Isao, Nagaoka   +12 more
openaire   +3 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Inhibition of safflower seed meal on quorum sensing of Chromobacterium violaceum ATCC12472

Siliao yanjiu, 2021
The experiment was to study the inhibitory effect of safflower seed meal on quorum sensing by taking the violacein produced by quorum sensing related Chromobacterium violaceum ATCC12472 as the evaluation index.
Hai-liang WANG, Jun-li NIU, Shan-shan NAN, Jia-cheng LI, Cun-xi NIE, Wen-ju ZHANG   +5 more
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Antibacterial Efficacy of Citrullus lanatus (Watermelon) Seeds Extracts against Wound Infecting Staphyloccocus aureus and Pseudomonas Aeruginosa

UMYU Journal of Microbiology Research
Watermelon seeds, originally from vine plants, are rich in nutrients and bioactive compounds.  This study aimed to assess the antibacterial efficacy of Citrullus lanatus (Watermelon) seed extracts against wound-infecting Staphylococcus aureus and ...
Musa, B., Shimfuo, B. Y., Muhammad, J., Bako, G. D., Sanusi, S. B.   +4 more
doaj   +1 more source

Inhibition of dengue virus serotype 2 in Vero cells with [Cu(2,4,5-triphenyl-1H-imidazole)2(H2O)2].Cl2

Infectious Disease Reports, 2020
Dengue fever and dengue hemorrhagic fever are transmitted to humans by the Aedes aegypti and Aedes albopictus mosquitoes, with an observed 30-fold increase in global incidence the last 50 years.
Teguh H. Sucipto, Fahimah Martak
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Summary of Drug Titrations Showing 50% Inhibitory Concentration, IC₅₀, for the P-gp^± Cell Lines Treated with Paclitaxel and Derivatives (and ± Verapamil).

, 2015
The IC50 values are given in nM. Values and errors (SE) shown are representative of n = 3 independent experiments.* P < 0.05 determined for IC50 for an analog relative to paclitaxel.‡ P < 0.05 determined for IC50 for an analog with improved potency ...
Richard F. Ludueña (751489), Sambasivarao Damaraju (102523), Ahmed T. Ayoub (747972), Carol E. Cass (102519), Mariusz Klobukowski (747973), Jack A. Tuszynski (160860), Marc St. George (318231), Philip Winter (291799), Asok Banerjee (751487), Cassandra D. M. Churchill (751488)   +9 more
core   +1 more source

The Antimicrobial Effects of the Alcoholic Extracts of Pomegranate (Punica Granatum) on the Planktonic Forms and Biofilm Structures of Six Pathogenic Bacteria

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2015
BACKGROUND AND OBJECTIVE In traditional medicine, pomegranate is used for the treatment of intestinal worms and diarrhea. This study aimed to examine the antibacterial activities of pomegranate extracts on biofilm structures and planktonic forms of six ...
Mehdi Hassanshahian, Zinab Mohsenipour
doaj