Results 51 to 60 of about 7,131,135 (287)

The effect of ethanol extract of Glycyrrhiza uralensis on the voltage-gated sodium channel subtype 1.4

Journal of Pharmacological Sciences, 2018
To investigate the inhibitory effect of Glycyrrhiza uralensis (G. uralensis) and its monomeric compounds on Nav1.4 voltage-gated sodium channels (VGSCs) and analyze the relationship between the content of its marker compounds and the inhibitory rate ...
Guangwei Zhu, Shengjun Ma, Xiwen Li, Peng Zhang, Lin Tang, Lijuan Cao, Aoxue Liu, Toru Sugita, Takehisa Tomoda   +8 more
doaj   +1 more source

Investigating the Antibacterial Effects of Synthetic Gamma-Lactam Heterocycles on Methicillin-Resistant Staphylococcus aureus Strains and Assessing the Safety and Effectiveness of Lead Compound MFM514

Molecules, 2023
Methicillin-resistant Staphylococcus aureus (MRSA) continues to be one of the main causes of hospital-acquired infections in all regions of the world, while linezolid is one of the only commercially available oral antibiotics available against this ...
Saiful Azmi Johari, Mastura Mohtar, Mohd Fazli Mohammat, Fatin Nur Ain Abdul Rashid, Muhamad Zulfaqar Bacho, Azman Mohamed, Mohamad Jemain Mohamad Ridhwan, Sharifah Aminah Syed Mohamad   +7 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Study on α-glucosidase inhibitory activity of 40 kinds of vegetables, tubers, and fruits in An Giang

Vietnam Journal of Science, Technology and Engineering, 2022
A study on the α-glucosidase inhibitory activity of 40 kinds of vegetables, tubers, and fruits found in the An Giang province was conducted. The results indicated that all 40 extracted samples displayed α-glucosidase inhibitory activity at a ...
Thi-My-Linh Lam, Minh-Tuan Le, Manh-Ha Bui   +2 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Phenylpyrazalopyrimidines as Tyrosine Kinase Inhibitors: Synthesis, Antiproliferative Activity, and Molecular Simulations

Molecules, 2020
N1-(α,β-Alkene)-substituted phenylpyrazolopyrimidine derivatives with acetyl and functionalized phenyl groups at α- and β-positions, respectively, were synthesized by the reaction of 3-phenylpyrazolopyrimidine (PhPP) with bromoacetone, followed by a ...
Bhupender S. Chhikara, Sajda Ashraf, Saghar Mozaffari, Nicole St. Jeans, Dindyal Mandal, Rakesh Kumar Tiwari, Zaheer Ul-Haq, Keykavous Parang   +7 more
doaj   +1 more source

Activity of propolis from Mexico on the proliferation and virulence factors of Candida albicans

BMC Microbiology, 2023
Background This research evaluated the anti-Candida albicans effect of Mexican propolis from Chihuahua. Chemical composition of the ethanolic extract of propolis was determined by GC-MS, HPLC-DAD, and HPLC-MS. The presence of anthraquinone, aromatic acid,
Mario Rodriguez-Canales, Yoli Mariana Medina-Romero, Marco Aurelio Rodriguez-Monroy, Uriel Nava-Solis, Sandra Isabel Bolaños-Cruz, Maria Jimena Mendoza-Romero, Jorge E. Campos, Ana Bertha Hernandez-Hernandez, Yolanda I. Chirino, Tonatiuh Cruz-Sanchez, Carlos Gerardo Garcia-Tovar, Maria Margarita Canales-Martinez   +11 more
doaj   +1 more source

Synthesis and spectroscopic study of novel mixed ligand formula “Artemisinin/Zn” and assessment of its inhibitory effect against “SARS-CoV-2″

Heliyon, 2023
Background: Herein, a newly synthesised mixed ligand artemisinin/zinc (Art/Zn) is chemically characterised and examined against SARS-CoV-2. Methods: The synthesised complex was thoroughly characterised using various spectroscopic methods (FT-IR, UV and ...
Fawziah A. Al-Salmi, Samy M. El-Megharbel, Reham Z. Hamza   +2 more
doaj   +1 more source

Identification of responders/non-responders to 5-fluorouracil based on individual 50% inhibitory area under the concentration curve of 5-fluorouracil obtained with collagen gel droplet-embedded culture-drug sensitivity test in colorectal cancer

Oncology Letters, 2011
We previously reported the 5-fluorouracil (5-FU) sensitivity of cancer cells obtained from colorectal cancer (CRC) patients using the collagen gel droplet-embedded culture-drug sensitivity test (CD-DST). Multiple drug concentrations and contact durations, and the area under the concentration curve (AUC) and growth inhibition rate (IR) were combined ...
Takumi, Ochiai, Kazuhiko, Nishimura, Tomoo, Watanabe, Masayuki, Kitajima, Akinori, Nakatani, Takashi, Marusasa, Tadasuke, Hashiguchi, Takayuki, Uchida, Naoki, Sakuyama, Tsuyoshi, Sato, Kennji, Kishine, Shunji, Futagawa, Isao, Nagaoka   +12 more
openaire   +3 more sources

Effectiveness of E cytotoxicity presented as a half maximal growth inhibitory concentration (CC₅₀).

, 2015
The CC50 was calculated for primary AML samples (top) and AML cell lines (bottom) at days: 4 and 2 respectively, when cultured at 2% serum.Effectiveness of E cytotoxicity presented as a half maximal growth inhibitory concentration (CC50).
Mary A. Selak (255992), Laura A. Garcia-Cid (730509), Martin Carroll (730510), Anna Kalota (7415)   +3 more
core   +1 more source