Results 51 to 60 of about 753,617 (295)

1,3,5-Triazine Nitrogen Mustards with Different Peptide Group as Innovative Candidates for AChE and BACE1 Inhibitors

Molecules, 2021
A series of new analogs of nitrogen mustards (4a–4h) containing the 1,3,5-triazine ring substituted with dipeptide residue were synthesized and evaluated for the inhibition of both acetylcholinesterase (AChE) and β-secretase (BACE1) enzymes.
Dawid Maliszewski, Agnieszka Wróbel, Beata Kolesińska, Justyna Frączyk, Danuta Drozdowska   +4 more
doaj   +1 more source

Evaluation of the individual 50% inhibitory area under the concentration curve of 5-fluorouracil based on the collagen gel droplet embedded culture drug sensitivity test in colorectal cancer

Molecular Medicine Reports, 2009
We have previously reported the 5-fluorouracil (5-FU) sensitivity of cancer cells from colorectal cancer (CRC) patients using the collagen gel droplet embedded culture-drug sensitivity test (CD-DST) under multiple drug concentrations and contact durations.
Takumi, Ochiai, Kazuhiko, Nishimura, Tomoo, Watanabe, Masayuki, Kitajima, Masataka, Tsuji, Akinori, Nakatani, Noboru, Nakayama, Takashi, Marusasa, Satomi, Mashiko, Isao, Nagaoka, Shunji, Futagawa   +10 more
openaire   +3 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Half-maximal inhibitory concentration (IC₅₀) values (nM) of MKP101 for human kinases.

, 2015
*The data, except for that of EGFR, are the values reported in reference [31].Half-maximal inhibitory concentration (IC50) values (nM) of MKP101 for human kinases.
Jiho Song (799714), Wonhee Suh (799719), Hong Khanh Nguyen (799717), Ara Kwon (799715), Kyung Hoon Min (799720), Doran Kim (799716), Bong-Yong Lee (799718), Jakyung Yoo (406971)   +7 more
core   +1 more source

Development of a Highly Sensitive and Specific Immunoassay for Determining Chrysoidine, A Banned Dye, in Soybean Milk Film

Molecules, 2011
A highly specific and sensitive indirect competitive enzyme-linked immunosorbent assay (icELISA）was developed for the first time for the detection of chrysoidine, a dye banned in soybean milk film.
Yuanming Sun, Yueming Jiang, Zhenlin Xu, Jinyi Yang, Haoxian Guo, Simon A. Haughey, Jin Liu, Lijun Song, Yudong Shen, Hongtao Lei   +9 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The rapid analysis of fungal growth in the presence of inhibitory effects [PDF]

, 2011
For fungal contamination of foodstuffs, there are no fast, reliable, automated techniques to examine growth, nor have any predictive models been developed to describe the growth in the same way as for bacteria. Traditional plating methods can take 3 to
Williams, Tyson
core  

Inhibitory concentration 50% (IC₅₀) values in μg/mL with standard error for two cyathostomin lines treated with either pyrantel or Cry5B.

, 2018
Inhibitory concentration 50% (IC50) values in μg/mL with standard error for two cyathostomin lines treated with either pyrantel or Cry5B.
Raffi V. Aroian (103098), Thanh-Thanh Nguyen (5236655), Melanie Miller (1579858), Yan Hu (30839), Bo Zhang (6559), Martin K. Nielsen (5236652)   +5 more
core   +1 more source

Investigating the Antibacterial Effects of Synthetic Gamma-Lactam Heterocycles on Methicillin-Resistant Staphylococcus aureus Strains and Assessing the Safety and Effectiveness of Lead Compound MFM514

Molecules, 2023
Methicillin-resistant Staphylococcus aureus (MRSA) continues to be one of the main causes of hospital-acquired infections in all regions of the world, while linezolid is one of the only commercially available oral antibiotics available against this ...
Saiful Azmi Johari, Mastura Mohtar, Mohd Fazli Mohammat, Fatin Nur Ain Abdul Rashid, Muhamad Zulfaqar Bacho, Azman Mohamed, Mohamad Jemain Mohamad Ridhwan, Sharifah Aminah Syed Mohamad   +7 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source