Results 61 to 70 of about 1,997,109 (329)

Evaluation of the individual 50% inhibitory area under the concentration curve of 5-fluorouracil based on the collagen gel droplet embedded culture drug sensitivity test in colorectal cancer

Molecular Medicine Reports, 2009
We have previously reported the 5-fluorouracil (5-FU) sensitivity of cancer cells from colorectal cancer (CRC) patients using the collagen gel droplet embedded culture-drug sensitivity test (CD-DST) under multiple drug concentrations and contact durations.
Takumi, Ochiai, Kazuhiko, Nishimura, Tomoo, Watanabe, Masayuki, Kitajima, Masataka, Tsuji, Akinori, Nakatani, Noboru, Nakayama, Takashi, Marusasa, Satomi, Mashiko, Isao, Nagaoka, Shunji, Futagawa   +10 more
openaire   +3 more sources

Role of histaminegic and calcium channels in the inhibitory effects of hydroalcoholic extract of matricaria recutita L. on isolated rabbit jejunum [PDF]

, 2011
Introduction: Considering the long traditional history of anti-inflammatory and anti-spasmodic effects of Matricria spices on the gastrointestinal system, the present study aimed to investigate the role of calcium channels and Histamine receptors in the ...
Badaghabadi, F., Bayat, H., Hoseini, S.F., Khori, V., Mazandarani, M., Moheimani, H., Pourabouk, M., Rajaei, M., Seifi, A.   +8 more
core  

The Role of Invasive Procedures in the Treatment of Complicated Gastrointestinal Graft‐Versus‐Host Disease in Pediatric Patients

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Gastrointestinal graft‐versus‐host disease (GI GVHD) following hematopoietic stem cell transplant is typically managed with medical therapy, but surgery and angioembolization may be warranted in selected cases with life‐threatening complications.
Gaia Brunetti, Giorgio Persano, Chiara Grimaldi, Pier Luigi Di Paolo, Carmen Malaspina, Francesco Quagliarella, Valerio Balassone, Anna Chiara Iolanda Contini, Gian Luigi Natali, Rita Alaggio, Ivan Pietro Aloi, Tamara Caldaro, Alessandro Crocoli   +12 more
wiley   +1 more source

Development of a Highly Sensitive and Specific Immunoassay for Determining Chrysoidine, A Banned Dye, in Soybean Milk Film

Molecules, 2011
A highly specific and sensitive indirect competitive enzyme-linked immunosorbent assay (icELISA）was developed for the first time for the detection of chrysoidine, a dye banned in soybean milk film.
Yuanming Sun, Yueming Jiang, Zhenlin Xu, Jinyi Yang, Haoxian Guo, Simon A. Haughey, Jin Liu, Lijun Song, Yudong Shen, Hongtao Lei   +9 more
doaj   +1 more source

Phenylpyrazalopyrimidines as Tyrosine Kinase Inhibitors: Synthesis, Antiproliferative Activity, and Molecular Simulations

Molecules, 2020
N1-(α,β-Alkene)-substituted phenylpyrazolopyrimidine derivatives with acetyl and functionalized phenyl groups at α- and β-positions, respectively, were synthesized by the reaction of 3-phenylpyrazolopyrimidine (PhPP) with bromoacetone, followed by a ...
Bhupender S. Chhikara, Sajda Ashraf, Saghar Mozaffari, Nicole St. Jeans, Dindyal Mandal, Rakesh Kumar Tiwari, Zaheer Ul-Haq, Keykavous Parang   +7 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The effect of ethanol extract of Glycyrrhiza uralensis on the voltage-gated sodium channel subtype 1.4

Journal of Pharmacological Sciences, 2018
To investigate the inhibitory effect of Glycyrrhiza uralensis (G. uralensis) and its monomeric compounds on Nav1.4 voltage-gated sodium channels (VGSCs) and analyze the relationship between the content of its marker compounds and the inhibitory rate ...
Guangwei Zhu, Shengjun Ma, Xiwen Li, Peng Zhang, Lin Tang, Lijuan Cao, Aoxue Liu, Toru Sugita, Takehisa Tomoda   +8 more
doaj   +1 more source

Development and validation of Triticum phytobiological method as an alternative procedure for investigating in vivo acute toxicity on mice [PDF]

, 2017
The goal of this study was to validate an alternative method for determining in vivo acute toxicity using vegetal material instead of laboratory animals, starting from the phytobiological method known also as the Triticum technique.
Anghel, Adriana, Chiriță, Cornel, Cristea, Aurelia N., Dinu, Mihaela, Olaru, Octavian, Ştefănescu, Emil   +5 more
core   +4 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Synthesis and spectroscopic study of novel mixed ligand formula “Artemisinin/Zn” and assessment of its inhibitory effect against “SARS-CoV-2″

Heliyon, 2023
Background: Herein, a newly synthesised mixed ligand artemisinin/zinc (Art/Zn) is chemically characterised and examined against SARS-CoV-2. Methods: The synthesised complex was thoroughly characterised using various spectroscopic methods (FT-IR, UV and ...
Fawziah A. Al-Salmi, Samy M. El-Megharbel, Reham Z. Hamza   +2 more
doaj   +1 more source