Results 101 to 110 of about 1,232,153 (317)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Inhibitory effect of gold nanoparticles on the D-ribose glycation of bovine serum albumin

, 2014
Weixi Liu,1 Menashi A Cohenford,1–3 Leslie Frost,3 Champika Seneviratne,4 Joel A Dain1 1Department of Chemistry, University of Rhode Island, Kingston, RI, USA; 2Department of Integrated Science and Technology, 3Department of Chemistry, Marshall ...
Dain JA, Seneviratne C, Cohenford MA, Frost L, Liu W   +4 more
core  

Role of cGMP as second messenger of adenosine in the inhibition of renin release

, 1988
Adenosine is known to be a potent inhibitor of renin release from the kidneys. The aim of this study was to investigate the transmembrane signalling avenue that the second messenger of adenosine causes inhibition of renal renin release.
Kurtz, Armin, Della Bruna, Roberto, Della Bruna, R., Bauer, Christian, Pfeilschifter, Josef, Pfeilschifter, J.   +5 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Remapped memory trace generates an inhibitory attentional effect

, 2016
PURPOSE: We perceive a stable visual world despite the retinal image is constantly shifted rapid eye movements (saccades), which normally occur 3-4 times a second.
Zhiguo Wang, Chuyao Yan
core  

Dietary apigenin potentiates the inhibitory effect of interferon-alpha on cancer cell viability through inhibition of 26S proteasome-mediated interferon receptor degradation

, 2016
Background: Type I interferons (IFN-alpha/beta) have broad and potent immunoregulatory and antiproliferative activities. However, it is still known whether the dietary flavonoids exhibit their antiviral and anticancer properties by modulating the ...
Liu, HW, Wang, F (reprint author), Chinese Acad Sci, Chengdu Inst Biol, 9 Sect 4 Renmin South Rd, Chengdu 610041, Peoples R China., He, YJ, Shen, XF, Wang, P, Yang, LJ, Li, S, Huang, JM, Wang, F   +8 more
core   +1 more source

Strategy for Sustainable Bio‐Value Chain Development: Algal Biomass Utilization Without Inhibitory Effects on Lactic Acid Production via Efficient Diluted Acid Hydrolysis of Brown Macroalga

GCB Bioenergy
Saccharina japonica, one of the most widely cultivated brown algae species, is considered a promising biorefinery feedstock due to its high carbohydrate content. Dilute acid hydrolysis can be performed to recover sugars from S.
Jihyun Bae, Jeongho Lee, Hyeok Ki Kwon, Giwon Lee, Taek Lee, Hyun Gyu Lim, Sang Woo Seo, Gyoo Yeol Jung, Hah Young Yoo, Chulhwan Park   +9 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source