Results 231 to 240 of about 148,630 (258)

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source

SSR4 sustains Tertiary Lymphoid Structures by Regulation Quality Control of N‐linked Glycosylation During B‐cell Differentiation Into Plasmacyte in Colorectal Cancer

Advanced Science, EarlyView.
SSR4, a TRAP component induced in B cells, governs BAFFR N‐glycosylation via DDOST to sustain NF‐κB signaling, B‐cell differentiation, and TLS maturation. Its loss impairs anti‐tumor immunity, while overexpression improves antibody glycosylation and ADCC, revealing a critical regulator for cancer immunotherapy.
Wei Zhao, Youcai Zhao, Haiyang Li, Bowen Yang, Siyan Lu, Xueting Fu, Caixia Zhang, Yirong Chen, Xiaofeng Bian, Xinghua Ma, Xiaobing Yang, Bin Wang, Yuan Fang, Lulu Yang, Yelin Zhao, Shuli Zhao   +15 more
wiley   +1 more source

Global error signal guides local optimization in mismatch calculation. [PDF]

Nat Commun
Meng JH, Wang XJ.
europepmc   +1 more source

Neuropeptide S modulation of learning and memory: a systematic review. [PDF]

Behav Brain Funct
Caragea VM, Jüngling K, Méndez-Couz M.
europepmc   +1 more source

Oxytocin attenuates fear learning via enhancing somatostatin interneuron-mediated local GABAergic inhibition in the prelimbic cortex. [PDF]

Sci Adv
Xu H, Li Y, Cui X, Zhang Y, Wu X, Zhuo SS, He M, Xiao L.   +7 more
europepmc   +1 more source

On the impact of tactile processing on motor cortex: how touch shapes motor behaviour. [PDF]

Brain Struct Funct
Zafarana A, Muret D, Farnè A, Tamè L.
europepmc   +1 more source

Neuropsychological effects of cannabis use by continent and age: a systematic review. [PDF]

Front Psychol
Venero-Hidalgo L, Carvajal F, Rodríguez de Fonseca F, Villanueva-Blasco VJ.   +3 more
europepmc   +1 more source

A brain-constrained neural model of cognition and language with NEST: transitioning from the Felix framework. [PDF]

Cogn Neurodyn
Carriere M, Dobler F, Plesser HE, Feledyn A, Tomasello R, Wennekers T, Pulvermüller F.   +6 more
europepmc   +1 more source