Results 41 to 50 of about 602,951 (277)
Presynaptic LRP4 promotes synapse number and function of excitatory CNS neurons
eLife, 2017 Precise coordination of synaptic connections ensures proper information flow within circuits. The activity of presynaptic organizing molecules signaling to downstream pathways is essential for such coordination, though such entities remain incompletely ...
Timothy J Mosca +3 more
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Electrolyte Gated Oxide Pseudodiode for Inhibitory Synapse Applications
, 2018 Recently, synaptic electronics are attracting increasing attention in neuromorphic engineering. Here, inhibitory synapses are proposed based on nanogranular phosphorous silicate glass gated indium tin oxide transistors operated in pseudodiode mode ...
Fei Yu +15 more
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Matched sizes of activating and inhibitory receptor/ligand pairs are required for optimal signal integration by human Natural Killer cells [PDF]
, 2010 It has been suggested that receptor-ligand complexes segregate or co-localise within immune synapses according to their size, and this is important for receptor signaling.
Brzostek, Joanna +58 more
core +1 more source
, 2013 The balance between excitatory and inhibitory synaptic inputs, which is governed by multiple synapse organizers, controls neural circuit functions and behaviors.
Jaewon Ko +8 more
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Common Ribs of Inhibitory Synaptic Dysfunction in the Umbrella of Neurodevelopmental Disorders
Frontiers in Molecular Neuroscience, 2018 The term neurodevelopmental disorder (NDD) is an umbrella term used to group together a heterogeneous class of disorders characterized by disruption in cognition, emotion, and behavior, early in the developmental timescale.
Rachel Ali Rodriguez +2 more
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Striatal Synapse Degeneration and Dysfunction Are Reversed by Reactivation of Wnt Signaling
Frontiers in Synaptic Neuroscience, 2021 Synapse degeneration in the striatum has been associated with the early stages of Parkinson’s and Huntington’s diseases (PD and HD). However, the molecular mechanisms that trigger synaptic dysfunction and loss are not fully understood.
Soledad Galli +4 more
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The Biochemical Anatomy of Cortical Inhibitory Synapses
PLoS ONE, 2012 Classical electron microscopic studies of the mammalian brain revealed two major classes of synapses, distinguished by the presence of a large postsynaptic density (PSD) exclusively at type 1, excitatory synapses. Biochemical studies of the PSD have established the paradigm of the synapse as a complex signal-processing machine that controls synaptic ...
Heller, Elizabeth +9 more
openaire +4 more sources
Modulating excitation through plasticity at inhibitory synapses [PDF]
Frontiers in Cellular Neuroscience, 2014 Learning is believed to depend on lasting changes in synaptic efficacy such as long-term potentiation and long-term depression. As a result, a profusion of studies has tried to elucidate the mechanisms underlying these forms of plasticity. Traditionally, experience-dependent changes at excitatory synapses were assumed to underlie learning and memory ...
Chevaleyre, Vivien, Piskorowski, Rebecca
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Molecular diversity underlying cortical excitatory and inhibitory synapse development
, 2018 The complexity and precision of cortical circuitries is achieved during development due to the exquisite diversity of synapse types that is generated in a highly regulated manner.
Favuzzi, Emilia +3 more
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Roles of Glial Cells in Sculpting Inhibitory Synapses and Neural Circuits
Frontiers in Molecular Neuroscience, 2017 Glial cells are essential for every aspect of normal neuronal development, synapse formation, and function in the central nervous system (CNS). Astrocytes secrete a variety of factors that regulate synaptic connectivity and circuit formation.
Ji Won Um
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