Results 1 to 10 of about 3,900 (114)
Redox-dependent synaptic clustering of gephyrin [PDF]
Nature CommunicationsReactive oxygen species (ROS) have been demonstrated to play central functions as signaling molecules thus extending their role beyond oxidative stress in disease and aging.
Maria-Theresa Gehling +9 more
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Impaired gephyrin G-domain trimerization and phase separation in a patient with developmental epileptic encephalopathy [PDF]
EMBO Molecular MedicineEpilepsy, a common neurological disorder is frequently linked to genetic variants in synaptic proteins. Here, we describe a de novo pathogenic missense variant in the gephyrin G-domain (G134R) identified in an individual with developmental delay ...
Emanuel H W Bruckisch +6 more
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Cryo-EM structures of higher order Gephyrin oligomers reveal principles of inhibitory postsynaptic scaffold organization [PDF]
Nature CommunicationsGephyrin, the principal scaffolding protein of inhibitory postsynaptic densities, clusters glycine and GABAA receptors via multivalent interactions. It features structured N and C terminal domains connected by an intrinsically disordered linker. Although
Diego Ortiz-López +12 more
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EMBO Molecular Medicine, 2015 Synaptic inhibition is essential for shaping the dynamics of neuronal networks, and aberrant inhibition plays an important role in neurological disorders.
Jochen C. Meier +2 more
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Gephyrin filaments represent the molecular basis of inhibitory postsynaptic densities [PDF]
Nature CommunicationsThe multifunctional protein gephyrin clusters inhibitory receptors at the postsynaptic membrane in the CNS. Gephyrin has been proposed to form the inhibitory postsynaptic density by liquid-liquid phase separation, involving a complex interplay between ...
Arthur Macha +8 more
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iScience, 2021 Summary: Gephyrin is critical for the structure, function, and plasticity of inhibitory synapses. Gephyrin mutations have been linked to various neurological disorders; however, systematic analyses of the functional consequences of these mutations are ...
Seungjoon Kim +7 more
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Palmitoylation of gephyrin controls receptor clustering and plasticity of GABAergic synapses. [PDF]
PLoS Biology, 2014 Postsynaptic scaffolding proteins regulate coordinated neurotransmission by anchoring and clustering receptors and adhesion molecules. Gephyrin is the major instructive molecule at inhibitory synapses, where it clusters glycine as well as major subsets ...
Borislav Dejanovic +7 more
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Gephyrin-independent GABA(A)R mobility and clustering during plasticity. [PDF]
PLoS ONE, 2012 The activity-dependent modulation of GABA-A receptor (GABA(A)R) clustering at synapses controls inhibitory synaptic transmission. Several lines of evidence suggest that gephyrin, an inhibitory synaptic scaffold protein, is a critical factor in the ...
Fumihiro Niwa +5 more
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A DARPin-based molecular toolset to probe gephyrin and inhibitory synapse biology
eLife, 2022 Neuroscience currently requires the use of antibodies to study synaptic proteins, where antibody binding is used as a correlate to define the presence, plasticity, and regulation of synapses. Gephyrin is an inhibitory synaptic scaffolding protein used to
Benjamin FN Campbell +4 more
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Deciphering the conformational dynamics of gephyrin-mediated collybistin activation
Biophysical Reports, 2022 Efficient neuronal signaling depends on the proper assembly of the postsynaptic neurotransmitter machinery. The majority of inhibitory synapses feature γ-aminobutyric acid type A (GABAA) receptors.
Nasir Imam +4 more
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