Results 1 to 10 of about 8,165 (212)

GABAA Receptor Subunits in Rat Testis and Sperm [PDF]

International Journal of Fertility and Sterility, 2008
Background γ-Aminobutyric acid (GABA) is considered to be the predominant inhibitory neurotransmitter in mammalian central nervous systems (CNS). There are two major classes of GABA receptors: GABAARs and GABABRs.
Abolghasem Esmaeili
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The potential role of astroglial GABAA receptors in autoimmune encephalitis associated with GABAA receptor antibodies and seizures

Epilepsia Open, 2023
The γ‐aminobutyric acid (GABA) is the main inhibitory transmitter in the central nervous system and GABA receptors mediate the inhibitory synaptic transmission.
Fatme Seval Ismail, Pedro M. Faustmann
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Age-related GABAergic differences in the primary sensorimotor cortex: A multimodal approach combining PET, MRS and TMS

NeuroImage, 2021
Healthy aging is associated with mechanistic changes in gamma-aminobutyric acid (GABA), the most abundant inhibitory neurotransmitter in the human brain.
Koen Cuypers, Melina Hehl, June van Aalst, Sima Chalavi, Mark Mikkelsen, Koen Van Laere, Patrick Dupont, Dante Mantini, Stephan P. Swinnen   +8 more
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Functional characterization of GABAA receptor-mediated modulation of cortical neuron network activity in microelectrode array recordings. [PDF]

PLoS ONE, 2017
The numerous γ-aminobutyric acid type A receptor (GABAAR) subtypes are differentially expressed and mediate distinct functions at neuronal level. In this study we have investigated GABAAR-mediated modulation of the spontaneous activity patterns of ...
Benjamin M Bader, Anne Steder, Anders Bue Klein, Bente Frølund, Olaf H U Schroeder, Anders A Jensen   +5 more
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FMRP regulates GABAA receptor channel activity to control signal integration in hippocampal granule cells

Cell Reports, 2022
Summary: Fragile X syndrome, the most common inherited form of intellectual disability, is caused by loss of fragile X mental retardation protein (FMRP).
Pan-Yue Deng, Ajeet Kumar, Valeria Cavalli, Vitaly A. Klyachko   +3 more
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Genetic inhibition of glutamate allosteric potentiation of GABAARs in mice results in hyperexcitability, leading to neurobehavioral abnormalities

MedComm, 2023
The imbalance between neuronal excitation and inhibition (E/I) in neural circuit has been considered to be at the root of numerous brain disorders. We recently reported a novel feedback crosstalk between the excitatory neurotransmitter glutamate and ...
Yehong Du, Junjie Li, Maoju Wang, Qiuyun Tian, Yayan Pang, Ya Wen, Dongchuan Wu, Yu Tian Wang, Zhifang Dong   +8 more
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Zolpidem Profoundly Augments Spared Tonic GABAAR Signaling in Dentate Granule Cells Ipsilateral to Controlled Cortical Impact Brain Injury in Mice

Frontiers in Systems Neuroscience, 2022
Type A GABA receptors (GABAARs) are pentameric combinations of protein subunits that give rise to tonic (ITonicGABA) and phasic (i.e., synaptic; ISynapticGABA) forms of inhibitory GABAAR signaling in the central nervous system.
Jeffery A. Boychuk, Jeffery A. Boychuk, Corwin R. Butler, Corwin R. Butler, Katalin Cs. Smith, Katalin Cs. Smith, Miklos B. Halmos, Bret N. Smith, Bret N. Smith, Bret N. Smith, Bret N. Smith   +10 more
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Characterization of inhibitory GABA-A receptor activation during spreading depolarization in brain slice. [PDF]

PLoS ONE, 2014
Spreading depolarization (SD) is a slowly propagating wave of near complete depolarizations of neurons and glia. Previous studies have reported large GABA releases during SD, but there is limited understanding of how GABA release and receptor activation ...
Isamu Aiba, C William Shuttleworth
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The serine hydrolase ABHD6 controls survival and thermally induced seizures in a mouse model of Dravet syndrome

Neurobiology of Disease, 2023
Evidence suggests that inhibition of α/β hydrolase-domain containing 6 (ABHD6) reduces seizures; however, the molecular mechanism of this therapeutic response remains unknown.
Ruth Westenbroek, Joshua Kaplan, Katie Viray, Nephi Stella   +3 more
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Understanding the GABA_A Receptor: Implications for Anesthesia and Beyond

Journal of Neuroanaesthesiology and Critical Care, 2023
Gamma-aminobutyric acid (GABA), a nonpeptide amino acid transmitter, is a major component of modern neuropharmacology and one of the most crucial target sites for general anesthetics and therapeutic drugs.
Padmaja Durga, Geetha Singham, Anupama Baradaa   +2 more
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