Delivery of GABAARs to Synapses Is Mediated by HAP1-KIF5 and Disrupted by Mutant Huntingtin [PDF]
Neuron, 2010 The density of GABA(A) receptors (GABA(A)Rs) at synapses regulates brain excitability, and altered inhibition may contribute to Huntington's disease, which is caused by a polyglutamine repeat in the protein huntingtin. However, the machinery that delivers GABA(A)Rs to synapses is unknown.
Twelvetrees, Alison E. +10 more
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Frontiers in Cellular Neuroscience, 2014 γ-Aminobutyric acid (GABA) depolarizes embryonic cerebrocortical neurons and continuous activation of the GABAA receptor (GABAAR) contributes to their tonic depolarization.
Tomonori eFurukawa +5 more
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Case Report: Anti-GABAA Receptor Encephalitis in a Dog
Frontiers in Veterinary Science, 2022 Autoantibodies against neurotransmitter receptors detected in cerebrospinal fluid (CSF) and serum are increasingly recognized in people with human autoimmune encephalitis causing severe neurological deficits, such as seizures and behavioral abnormalities.
Enrice I. Huenerfauth +4 more
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Diazepam Accelerates GABAAR Synaptic Exchange and Alters Intracellular Trafficking [PDF]
, 2019 Despite 50+ years of clinical use as anxiolytics, anti-convulsants, and sedative/hypnotic agents, the mechanisms underlying benzodiazepine (BZD) tolerance are poorly understood.
Matthew J. Bambino +4 more
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Mass spectrometric detection and characterization of atypical membrane-bound zinc-sensitive phosphatases modulating GABAA receptors. [PDF]
PLoS ONE, 2014 GABAA receptor (GABAAR) function is maintained by an endogenous phosphorylation mechanism for which the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is the kinase.
Mounia SidAhmed-Mezi +6 more
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α4βδ-GABAARs in the hippocampal CA1 as a biomarker for resilience to activity-based anorexia [PDF]
Neuroscience, 2014 Anorexia nervosa (AN) is a psychiatric illness characterized by restricted eating and an intense fear of gaining weight. Most individuals with AN are females, diagnosed first during adolescence, 40-80% of whom exhibit excessive exercise, and an equally high number with a history of anxiety disorder.
C, Aoki +5 more
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Zinc Inhibits the GABAAR/ATPase during Postnatal Rat Development: The Role of Cysteine Residue
, 2023 Zinc ions (Zn2+) are concentrated in various brain regions and can act as a neuromodulator, targeting a wide spectrum of postsynaptic receptors and enzymes.
Sergey A. Menzikov +4 more
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Alterations in GABAA-Receptor Trafficking and Synaptic Dysfunction in Brain Disorders
Frontiers in Cellular Neuroscience, 2019 GABAA receptors (GABAAR) are the major players in fast inhibitory neurotransmission in the central nervous system (CNS). Regulation of GABAAR trafficking and the control of their surface expression play important roles in the modulation of the strength ...
Miranda Mele +5 more
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The Detection of a GABAAR β3 Subunit in an Affinity-Purified Preparation of the GABAAR-Associated Cl-/HCO3 --ATPase Isolated from Rat Brain [PDF]
Biochemistry & Molecular Biology Journal, 2017 Background: The Cl-/HCO3--ATPase from animal brain is a new primary active Cl-- transport system that is coupled to the GABAA receptor (GABAAR). The structural coupling of the enzyme with GABAAR, however, has not been confirmed by the presence of GABAAR subunits within the purified protein complex.
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The Cerebellar GABAAR System as a Potential Target for Treating Alcohol Use Disorder [PDF]
, 2018 In the brain, fast inhibitory neurotransmission is mediated primarily by the ionotropic subtype of the gamma-aminobutyric acid (GABA) receptor subtype A (GABAAR). It is well established that the brain's GABAAR system mediates many aspects of neurobehavioral responses to alcohol (ethanol; EtOH). Accordingly, in both preclinical studies and some clinical
David J, Rossi, Ben D, Richardson
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