Results 61 to 70 of about 8,165 (212)

Influence of GABA_AR Monoliganded States on GABAergic Responses [PDF]

The Journal of Neuroscience, 2011
To reach the open state, the GABAAreceptor (GABAAR) is assumed to bind two agonist molecules. Although it is currently believed that GABAAR could also operate in the monoliganded state, the gating properties of singly bound GABAAR are poorly understood and their physiological role is still obscure.
PETRINI, E. M, NIEUS, T, RAVASENGA,T, SUCCOL, F, GUAZZI, STEFANIA, BENFENATI, F, BARBERIS, A.   +6 more
openaire   +3 more sources

Tumor Necrosis Factor Alpha Mediates GABAA Receptor Trafficking to the Plasma Membrane of Spinal Cord Neurons In Vivo

Neural Plasticity, 2012
The proinflammatory cytokine TNFα contributes to cell death in central nervous system (CNS) disorders by altering synaptic neurotransmission. TNFα contributes to excitotoxicity by increasing GluA2-lacking AMPA receptor (AMPAR) trafficking to the neuronal
Ellen D. Stück, Randolph N. Christensen, J. Russell Huie, C. Amy Tovar, Brandon A. Miller, Yvette S. Nout, Jacqueline C. Bresnahan, Michael S. Beattie, Adam R. Ferguson   +8 more
doaj   +1 more source

Human Hyperekplexic Mutations in Glycine Receptors Disinhibit the Brainstem by Hijacking GABAA Receptors

iScience, 2019
Summary: Hyperekplexia disease is usually caused by naturally occurring point mutations in glycine receptors (GlyRs). However, the γ-aminobutyric acid type A receptor (GABAAR) seems to be also involved regarding the therapeutic basis for hyperekplexia ...
Guichang Zou, Qi Chen, Kai Chen, Xin Zuo, Yushu Ge, Yiwen Hou, Tao Pan, Huilin Pan, Dan Liu, Li Zhang, Wei Xiong   +10 more
doaj   +1 more source

Electroacupuncture-induced activation of GABAergic system alleviates airway inflammation in asthma model by suppressing TLR4/MyD88/NF-κB signaling pathway

Chinese Medical Journal, 2023
. Background:. Electroacupuncture (EA) has been shown to attenuate airway inflammation in asthmatic mice; however, the underlying mechanism is not fully understood.
Ruisong Gong, Xiaowen Liu, Jing Zhao, Jing Ni   +3 more
doaj   +1 more source

Pragmatic screening for autoimmune‐associated epilepsy in drug‐resistant epilepsy of unknown etiology in resource‐limited settings: A hypothesis‐generating study

Epileptic Disorders, EarlyView.
Abstract Objective To evaluate the feasibility of investigating autoimmune etiology in adults with drug‐resistant epilepsy (DRE) of unknown origin in resource‐limited settings and to develop a pragmatic, hypothesis‐generating screening approach to guide autoantibody testing. Methods A prospective observational study including adults with DRE of unknown
Tomásia O. de H. M. Frezatti, Ricardo L. Saute, Veriano Alexandre Júnior, Frederico N. Nakano, Marina T. R. P. Dalio, Tonicarlo R. Velasco, João P. Leite, Antônio Carlos dos Santos, Vanessa D. Marques, Américo C. Sakamoto   +9 more
wiley   +1 more source

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source

KCC2 receptor upregulation potentiates antinociceptive effect of GABAAR agonist on remifentanil-induced hyperalgesia

Molecular Pain, 2022
GABAergic system disinhibition played an important role in the pathogenesis of remifentanil-induced hyperalgesia (RIH). K + -Cl - -cotransporter-2 (KCC2) has the potential to enhance the strength of GABAergic signaling function.
Yuan Gao, Wenqiang Zhan, Yushi Jin, Xiaodan Chen, Jinxia Cai, Xiaotian Zhou, Xinyi Huang, Qimin Zhao, Weijian Wang, Jiehao Sun   +9 more
openaire   +2 more sources

Chronic intermittent ethanol regulates hippocampal GABA(A) receptor delta subunit gene expression

Frontiers in Cellular Neuroscience, 2015
Chronic ethanol consumption causes structural and functional reorganization in the hippocampus and induces alterations in the gene expression of gamma-aminobutyric acid type A receptors (GABAARs).
Paolo eFollesa, Gabriele eFloris, Gino Paolo Asuni, Antonio eIbba, Maria Giuseppina eTocco, Luca eZicca, Beniamina eMercante, Franca eDeriu, Giorgio eGorini   +8 more
doaj   +1 more source

The Influence of Regional Distribution and Pharmacologic Specificity of GABAAR Subtype Expression on Anesthesia and Emergence [PDF]

, 2017
Anesthetics produce unconsciousness by modulating ion channels that control neuronal excitability. Research has shown that specific GABAA receptor (GABAAR) subtypes in particular regions of the central nervous system contribute to different ...
Iris Speigel, Edyta K. Bichler, Paul S. García   +2 more
core   +1 more source

Early Remission of Cerebrospinal Fluid Interleukin‐6 After Initial Immunotherapy Predicts a Good Prognosis in Autoimmune Encephalitis

Neurology and Clinical Neuroscience, EarlyView.
ABSTRACT Background Autoimmune encephalitis therapy requires adjusting the regimen based on therapeutic response; however, clinical indicators of this response remain unknown. Aim To determine the predictive capability of cerebrospinal fluid (CSF), electroencephalography (EEG), and brain magnetic resonance imaging (MRI) in identifying responders to ...
Yuta Madokoro, Yuto Uchida, Hiroyasu Inoue, Toyohiro Sato, Teppei Fujioka, Masayuki Mizuno, Shoji Kawashima, Masahiro Oomura, Noriyuki Matsukawa   +8 more
wiley   +1 more source