Results 51 to 60 of about 8,165 (212)
Signal Transduction and Targeted Therapy, 2022 Maintaining a proper balance between the glutamate receptor-mediated neuronal excitation and the A type of GABA receptor (GABAAR) mediated inhibition is essential for brain functioning; and its imbalance contributes to the pathogenesis of many brain ...
Ya Wen +12 more
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Gephyrin plays a key role in BDNF-dependent regulation of amygdala surface GABAARs [PDF]
Neuroscience, 2013 Brain-derived neurotrophic factor (BDNF) is critically involved in synaptic plasticity and neurotransmission. Our lab has previously found that BDNF activation of neurotrophic tyrosine kinase, receptor, type 2 (TrkB) is required for fear memory formation and that GABAA receptor (GABAAR) subunits and the GABAA clustering protein gephyrin are dynamically
L, Mou +3 more
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GABAAR Modulator for Postpartum Depression
Cell, 2019 During the postpartum period, the brain's inhibitory GABAA receptors may not recover in time following their reduced numbers during pregnancy. This is likely the cause of postpartum depression prevalent in ∼12% of childbearing women. A new therapy for this condition consists of administering a synthetic neurosteroid during the postpartum period to ...
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Interactions between GHRH and GABAARs in the brains of patients with epilepsy and in animal models of epilepsy [PDF]
Scientific Reports, 2017 AbstractGrowth hormone releasing hormone (GHRH) has recently been shown to increase the level of γ-aminobutyric acid (GABA) and activate GABA receptors (GABARs) in the cerebral cortex. GABA is an inhibitory neurotransmitter that can inhibit seizures. Does GHRH enhance the inhibitory effect of GABA to prevent epilepsy by increasing the GABA level and ...
Tang, Shirong +7 more
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Single Ethanol Withdrawal Regulates Extrasynaptic δ-GABAA Receptors Via PKCδ Activation
Frontiers in Molecular Neuroscience, 2018 Alcohol (ethanol, EtOH) is one of the most widely abused drugs with profound effects on brain function and behavior. GABAA receptors (GABAARs) are one of the major targets for EtOH in the brain.
Juan Chen +9 more
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GABAaR was upregulated in rd1 mouse retina.
, 2015 A) Representative blots of GABAaR-α1 and β-tubulin in adult wild-type and rd1 mouse retinas. B) The expression levels of GABAa (GABAaR-α1 to β-tubulin ratio; mean±SD) were significantly higher in rd1 mouse retina than in wild-type (n = 10).
Abhinaba Ghosh (716735) +4 more
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HIV gp120 upregulates tonic inhibition through α5-containing GABAARs
Neuropharmacology, 2019 HIV-Associated Neurocognitive disorder (HAND) affects nearly half of infected patients. The HIV envelope protein gp120 is shed by infected cells and is a potent neurotoxin in vitro that reproduces many aspects of HAND when expressed in vivo. Here, we show that HIV gp120 increases the amplitude of a tonic current mediated by γ-aminobutyric acid type-A ...
Matthew V, Green, Stanley A, Thayer
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Frontiers in Molecular Neuroscience, 2018 Gamma aminobutyric acid (GABA) subtype A receptors (GABAARs) are integral membrane ion channels composed of five individual proteins or subunits. Up to 19 different GABAAR subunits (α1–6, β1–3, γ1–3, δ, ε, θ, π, and ρ1–3) have been identified, resulting ...
Ethan A. Everington +3 more
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Neurobiology of Disease, 2020 ARFGEF1 encodes a guanine exchange factor involved in intracellular vesicle trafficking, and is a candidate gene for childhood genetic epilepsies. To model ARFGEF1 haploinsufficiency observed in a recent Lennox Gastaut Syndrome patient, we studied a ...
JiaJie Teoh +12 more
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The Action of Positive Allosteric Modulators of the GABAAR Can Be Reversed by Novel Spiro Barbiturates [PDF]
GABAARs are pentameric ligand-gated ion channels that play a major role in mediating inhibition in the CNS. They are the target of many widely used positive allosteric modulators (PAMs) of GABAARs such as general anesthetics, sedatives, antiepileptics ...
Keith W., Miller +4 more
core +2 more sources