Results 31 to 40 of about 8,165 (212)
Neurobiology of Disease, 2014 Cerebral ischemia is characterized by an early disruption of GABAergic neurotransmission contributing to an imbalance of the excitatory/inhibitory equilibrium and neuronal death, but the molecular mechanisms involved are not fully understood.
Miranda Mele +4 more
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GABAAR Plasticity during Pregnancy: Relevance to Postpartum Depression [PDF]
, 2008 SummaryFluctuating neurosteroid levels over the ovarian cycle modulate neuronal excitability through effects on GABAA receptors (GABAARs). The large increase in progesterone-derived neurosteroids during pregnancy and their precipitous decline at ...
Maguire, Jamie, Mody, Istvan
core +1 more source
, 2022 Epilepsy and migraine are among the most prevalent neurological disorders. By being comorbid, the presence of one disorder increases the likelihood of the other.
Lin, Gong, Xiao, Ding
core +1 more source
Subtype selective y-Aminobutyric acid type A receptor (GABAAR) modulators acting at the benzodiazepine binding site: An update [PDF]
, 2020 γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter within the central nervous system (CNS) with fast, transsynaptic, and modulatory extrasynaptic effects being mediated by the ionotropic GABA type A receptors (GABAARs).
Ward S. E. +7 more
core +1 more source
Disrupted GABAAR trafficking and synaptic inhibition in a mouse model of Huntington's disease [PDF]
Neurobiology of Disease, 2012 Growing evidence suggests that Huntington's disease (HD), a neurodegenerative movement disorder caused by the mutant huntingtin (htt) with an expanded polyglutamine (polyQ) repeat, is associated with the altered intracellular trafficking and synaptic function.
Eunice Y. Yuen +3 more
openaire +3 more sources
The role of GABAAR phosphorylation in the construction of inhibitory synapses and the efficacy of neuronal inhibition [PDF]
Biochemical Society Transactions, 2009 GABAARs [GABA (γ-aminobutyric acid) type-A receptors] are heteropentameric chloride-selective ligand-gated ion channels that mediate fast inhibition in the brain and are key therapeutic targets for benzodiazepines, barbiturates, neurosteroids and general anaesthetics.
Mansi, Vithlani, Stephen J, Moss
openaire +2 more sources
Targeting GABAAR-Associated Proteins: New Modulators, Labels and Concepts
Frontiers in Molecular Neuroscience, 2019 γ-aminobutyric acid type A receptors (GABAARs) are the major mediators of synaptic inhibition in the brain. Aberrant GABAAR activity or regulation is observed in various neurodevelopmental disorders, neurodegenerative diseases and mental illnesses ...
Vladimir Khayenko +3 more
doaj +1 more source
GABA not only a neurotransmitter: osmotic regulation by GABAAR signalling [PDF]
, 2012 In neurons the anionic channel γ-aminobutyric (GABA) A receptor (GABAAR) plays a central role in mediating both the neurotrophic and neurotransmitter role of GABA. Activation of this receptor by GABA also affects the function of non-neuronal cells in the
Francesca eCiccolini +5 more
core +1 more source
Stoichiometric Pore Mutations of the GABAAR Reveal a Pattern of Hydrogen Bonding with Picrotoxin [PDF]
Biophysical Journal, 2008 Picrotoxin (PTX) is a noncompetitive antagonist of many ligand-gated ion channels, with a site of action believed to be within the ion-conducting pore. In the A-type gamma-aminobutyric acid receptor, a threonine residue in the second transmembrane domain is of particular importance for the binding of, and ultimate inhibition by, PTX.
Erkkila, Brian E. +2 more
openaire +2 more sources
Differential Coassembly of α1-GABAARs Associated with Epileptic Encephalopathy [PDF]
The Journal of Neuroscience, 2020 GABAA receptors (GABAARs) are profoundly important for controlling neuronal excitability. Spontaneous and familial mutations to these receptors feature prominently in excitability disorders and neurodevelopmental deficits following disruption to GABA-mediated inhibition.
Hannan, S +9 more
openaire +5 more sources