Results 21 to 30 of about 8,165 (212)

Hippocampal Astrocytes Impact Postnatal Development of Inhibitory Connections, Parvalbumin Levels, Social, and Spatial Navigation Behaviors in a Mouse Model of Fragile X Syndrome. [PDF]

J Neurochem
Astrocyte‐specific postnatal deletion of Fmr1 affects GABAergic gene expression and phasic inhibition of CA1 neurons in the hippocampus. While GABA transport in astrocytes does not alter tonic inhibition of CA1 pyramidal cells, it affects PV levels and is implicated in impaired spatial memories and social behaviors in astrocyte‐specific Fmr1 cKO mice ...
Wagner VA, Maples S, Thapa R, Wimberly J, Pettijohn E, Varallo A, Rais M, Sutley-Koury S, Hickmott P, Ethell IM.   +9 more
europepmc   +2 more sources

Relapses, Comorbidities, and Predictors of Outcome in Anti-GABA_A Receptor Encephalitis. [PDF]

Ann Neurol
Objectives To characterize the magnetic resonance imaging (MRI) lesion dynamics, comorbidities, predictors of relapse, and outcomes in anti‐γ‐aminobutyric acid type A receptor (GABAAR) encephalitis, and assess the utility of LIM‐domain‐only‐protein 5 (LMO5) antibodies as tumor markers.
Papi C, Milano C, Marmolejo L, Serafim AB, Aguilar E, Guasp M, Fonseca E, Simabukuro MM, Iorio R, Fukami Y, Santos MLSF, Miwa T, Araga T, Uchida Y, Kurihara M, Okada S, Garcia LV, Kaida K, Cunha NSCD, Vogrig A, Lamblin F, de Vries JM, Dutra LA, Höftberger R, Titulaer MJ, Planagumà J, Sabater L, Martinez-Hernandez E, Armangué T, Graus F, Iizuka T, Dalmau J, Spatola M, Anti‐GABAAR encephalitis study group.   +33 more
europepmc   +2 more sources

Regulation of GABAARs by Phosphorylation [PDF]

, 2015
γ-Aminobutyric acid type A receptors (GABAARs) are the principal mediators of fast synaptic inhibition in the brain as well as the low persistent extrasynaptic inhibition, both of which are fundamental to proper brain function. Thus unsurprisingly, deficits in GABAARs are implicated in a number of neurological disorders and diseases.
Yasuko, Nakamura, Laura M, Darnieder, Tarek Z, Deeb, Stephen J, Moss   +3 more
openaire   +2 more sources

On the Path from Proteomics to Function: GABAAR Trafficking Takes a Turn [PDF]

Neuron, 2018
There are significant challenges in identifying receptor-specific functional interactors in vivo. In this issue of Neuron, Ge et al. (2018) identify a novel GABAA receptor (GABAAR)-interacting protein, Clptm1, that regulates forward trafficking of GABAARs and inhibitory transmission.
Yoav, Noam, Susumu, Tomita
openaire   +2 more sources

Inhibition of GABAAR or Application of Lactobacillus casei Zhang Alleviates Ulcerative Colitis in Mice: GABAAR as a Potential Target for Intestinal Epithelial Renewal and Repair

, 2022
Emerging evidence indicates that the gamma−aminobutyric acid type A receptor (GABAAR) and Lactobacillus casei Zhang regulate colitis in a variety of ways, such as by participating in host immune and inflammatory responses, altering the gut ...
Li, Dan, Ma, Yunfei, Jing Lan, Deng, Ziteng, Lan, Jing, Qiuzhen Wang, Ziteng Deng, Yunfei Ma, Fan, Kai, Kai Fan, Jianyu Chang, Wang, Qiuzhen, Chang, Jianyu, Dan Li   +13 more
core   +1 more source

Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse Colon [PDF]

, 2014
The enteric nervous system (ENS) provides the intrinsic neural control of the gastrointestinal tract (GIT) and regulates virtually all GI functions.
Seifi, Mohsen, Mills, Jeremy, Lambert, Jeremy J., Swinny, Jerome D., Brown, James F., Bhandari, Pradeep, Rudolph, Uwe, Belelli, Delia   +7 more
core   +1 more source

Heterogeneous GABAA receptor subunit expression in pediatric epilepsy patients

Neurobiology of Disease, 2005
The γ-amino-butyric acid type A receptors (GABAAR) are a heteropentameric receptor complex, composed of 16 possible subunits in various combinations, forming a ligand-gated ion channel.
Brenda E. Porter, Guojun Zhang, Juanita Celix, Fu-chun Hsu, YogendraSinh H. Raol, Albert Telfeian, Paul R. Gallagher, Douglas A. Coulter, Amy R. Brooks-Kayal   +8 more
doaj   +1 more source

GABAAR isoform and subunit structural motifs determine synaptic and extrasynaptic receptor localisation [PDF]

Neuropharmacology, 2020
GABAA receptors (GABAARs) are the principal inhibitory neurotransmitter receptors in the central nervous system. They control neuronal excitability by synaptic and tonic forms of inhibition mostly mediated by different receptor subtypes located in specific cell membrane subdomains.
Saad Hannan, Marielle Minere, Joseph Harris, Pablo Izquierdo, Philip Thomas, Becky Tench, Trevor G. Smart   +6 more
openaire   +3 more sources

Assembly rules for GABAA receptor complexes in the brain

eLife, 2017
GABAA receptor (GABAAR) pentamers are assembled from a pool of 19 subunits, and variety in subunit combinations diversifies GABAAR functions to tune brain activity.
James S Martenson, Tokiwa Yamasaki, Nashid H Chaudhury, David Albrecht, Susumu Tomita   +4 more
doaj   +1 more source

Anti-γ-aminobutyric acid-A receptor encephalitis with refractory seizures and cognitive impairment in a young woman: A case report

Frontiers in Neurology, 2022
Anti-γ-aminobutyric acid-A receptor (GABAAR) encephalitis is an underappreciated cause of autoimmune encephalitis and remains refractory to antiepileptic therapies unless autoimmune responses are addressed.
Xue Yang, Bo Deng, Shengjun Wang, Xiaotang Wang, Lili Cao, Xiangjun Chen, Xiuhe Zhao   +6 more
doaj   +1 more source