Results 11 to 20 of about 8,165 (212)

Activity-Dependent Tuning of Inhibitory Neurotransmission Based on GABAAR Diffusion Dynamics [PDF]

Neuron, 2009
SummaryAn activity-dependent change in synaptic efficacy is a central tenet in learning, memory, and pathological states of neuronal excitability. The lateral diffusion dynamics of neurotransmitter receptors are one of the important parameters regulating
Lévi, Sabine, Schweizer, Claude, Racine, Victor, Triller, Antoine, Sibarita, Jean-Baptiste, Mikoshiba, Katsuhiko, Bannai, Hiroko, Inoue, Takafumi, Launey, Thomas   +8 more
core   +4 more sources

γ2 GABAAR Trafficking and the Consequences of Human Genetic Variation [PDF]

Frontiers in Cellular Neuroscience, 2018
GABA type A receptors (GABAARs) mediate the majority of fast inhibitory neurotransmission in the central nervous system (CNS). Most prevalent as heteropentamers composed of two α, two β, and a γ2 subunit, these ligand-gated ionotropic chloride channels ...
Joshua M. Lorenz-Guertin, Matthew J. Bambino, Tija C. Jacob   +2 more
doaj   +2 more sources

Role of GABAAR in the Transition From Acute to Chronic Pain and the Analgesic Effect of Electroacupuncture on Hyperalgesic Priming Model Rats

Frontiers in Neuroscience, 2021
Chronic pain is a costly health problem that impairs health-related quality of life when not effectively treated. Regulating the transition from acute to chronic pain is a new therapeutic strategy for chronic pain that presents a major clinical challenge.
Sisi Wang, Junying Du, Danning Xi, Fangbing Shao, Mengting Qiu, Xiaomei Shao, Yi Liang, Boyi Liu, Xiaomin Jin, Jianqiao Fang, Junfan Fang   +10 more
doaj   +2 more sources

Fast Regulation of GABAAR Diffusion Dynamics by Nogo-A Signaling [PDF]

Cell Reports, 2019
Summary: Precisely controlling the excitatory and inhibitory balance is crucial for the stability and information-processing ability of neuronal networks.
Steffen Fricke, Kristin Metzdorf, Melanie Ohm, Stefan Haak, Martin Heine, Martin Korte, Marta Zagrebelsky   +6 more
doaj   +5 more sources

Altered reactivity of central amygdala to GABAAR antagonist in the BACHD rat model of Huntington disease

Neuropharmacology, 2017
International audienceIn Huntington's disease (HD), dysfunctional affective processes emerge as key symptoms of disturbances. In human HD and transgenic rat models of the disease, the amygdala was previously shown to have a reduced volume and to carry a ...
Lamirault, Charlotte, Yu-Taeger, Libo, Doyère, Valérie, Nguyen, Huu Phuc, Charlotte Lamirault, Valérie Doyère, Riess, Olaf, Olaf Riess, El Massioui, Nicole, Nicole El Massioui, Huu Phuc Nguyen, Libo Yu-Taeger   +11 more
core   +3 more sources

Neonatal seizures and GABAergic drugs: Scylla and Charybdis? [PDF]

Epilepsia Open
Abstract Neonates have a high incidence of seizures that are frequently difficult to control with conventional first‐line anti‐seizure medications, which are gamma‐aminobutyric acid (GABA) agonists. The reasons for this clinical problem are multifold but are likely related to the unique physiology of the immature nervous system. Specifically, the early
Thompson KW, Suchomelova L, Wasterlain CG.   +2 more
europepmc   +2 more sources

Spinal Mechanisms of Testosterone Involved in Itch Regulation. [PDF]

CNS Neurosci Ther
Testosterone serves as an endogenous anti‐pruritic hormone underlying sex‐dependent itch differences. In the spinal dorsal horn, testosterone binds androgen receptors on GABAergic interneurons to enhance GABA release, suppressing GRPR+ − pruriceptive neurons through GABAA receptors and alleviating acute/chronic itch alongside itch‐comorbid anxiety ...
Chen L, Wang X, Cheng L, Li P, Wu Z, Li H.   +5 more
europepmc   +2 more sources

Regulation of GABAARs by Transmembrane Accessory Proteins

Trends in Neurosciences, 2021
The vast majority of fast inhibitory transmission in the brain is mediated by GABA acting on GABAA receptors (GABAARs), which provides inhibitory balance to excitatory drive and controls neuronal output. GABAARs are also effectively targeted by clinically important drugs for treatment in a number of neurological disorders. It has long been hypothesized
Wenyan, Han, Ryan D, Shepard, Wei, Lu
openaire   +3 more sources

Expanding GABAAR pharmacology via receptor-associated proteins

Current Opinion in Pharmacology, 2021
Drugs directly targeting γ-aminobutyric acid type A receptors (GABAARs), the major mediators of fast synaptic inhibition, contribute significantly to today's neuropharmacology. Emerging evidence establishes intracellularly GABAAR-associated proteins as the central players in determining cellular and subcellular GABAergic input sites, thereby providing ...
Clemens, Schulte, Hans Michael, Maric
openaire   +2 more sources

14-3-3ζ mediates GABAAR activation by interacting with BIG1

Molecular Neurobiology, 2022
Abstract Most fast synaptic inhibitions in the mammalian brain are mediated by GABAA receptors (GABAARs). An appropriate level of GABAAR expression at the cell surface is essential for neurodevelopment and the efficacy of GABAergic synaptic transmission.
Cuixian Li, Shen Huang, Jin Peng, Tianguo Hong, Chun Zhou, Jie Tang   +5 more
openaire   +2 more sources