Results 11 to 20 of about 5,161 (196)

Gephyrin, the enigmatic organizer at GABAergic synapses [PDF]

Frontiers in Cellular Neuroscience, 2012
GABAA receptors are clustered at synaptic sites to achieve a high density of postsynaptic receptors opposite the input axonal terminals. This allows an efficient propagation of GABA mediated signals, which mostly result in neuronal inhibition.
Verena Eva Tretter, Jayanta eMukherjee, Hans Michael Maric, Hermann eSchindelin, Werner eSieghart, Stephen J. Moss   +5 more
doaj   +8 more sources

Gephyrin Neurological Autoimmunity. [PDF]

Ann Neurol
Gephyrin is a postsynaptic scaffold protein essential for inhibitory neurotransmission. Gephyrin‐immunoglobulin G (IgG) was reported, decades ago, in a single case of paraneoplastic stiff‐person‐like syndrome, but its broader clinical relevance remains unknown.
Pantuliano MC, Arlt FA, Arenson N, Basuroski ID, Dubey D, Lesnick CE, Mills JR, Pittock SJ, Zekeridou A, Lane MA, McKeon A.   +10 more
europepmc   +3 more sources

GPHN (gephyrin) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2002
Review on GPHN (gephyrin), with data on DNA, on the protein encoded, and where the gene is ...
David-Watine, B
core   +3 more sources

Gephyrin clustering is required for the stability of GABAergic synapses [PDF]

Molecular and Cellular Neuroscience, 2007
Although gephyrin is an important postsynaptic scaffolding protein at GABAergic synapses, the role of gephyrin for GABAergic synapse formation and/or maintenance is still under debate.
Li, Rong-Wen, Jiang, Min, de Blas, Angel L, Yu, Wendou, Chen, Gong, Miralles, Celia P   +5 more
core   +3 more sources

Incorporation of a gephyrin-binding motif targets NMDA receptors to gephyrin-rich domains in HEK 293 cells.

European Journal of Neuroscience, 1999
The peripheral membrane protein gephyrin is essential for the postsynaptic localization of inhibitory glycine receptors (GlyRs). Binding of gephyrin to the GlyR beta subunit is mediated by a sequence motif located in the intracellular loop region ...
Betz, H., Kins, S., Kuhse, J., Bodo Laube, Stefan Kins, Kirsch, J., Joachim Kirsch, Jochen Kuhse, Laube, Bodo, Heinrich Betz   +9 more
core   +3 more sources

Collybistin splice variants differentially interact with gephyrin and Cdc42 to regulate gephyrin clustering at GABAergic synapses [PDF]

Journal of Cell Science, 2011
Collybistin (CB) is a guanine-nucleotide-exchange factor (GEF) selectively activating Cdc42. CB mutations cause X-linked mental retardation due to defective clustering of gephyrin, a postsynaptic protein associated with both glycine and GABA(A) receptors.
Shiva K. Tyagarajan, Himanish Ghosh, Jean-Marc Fritschy, Ghosh, H, Kirsten Harvey, Harvey, K, Tyagarajan, S K, Fritschy, J M, Tyagarajan SK, Harvey K, Ghosh H, Fritschy JM   +11 more
core   +6 more sources

Modulation of gephyrin-glycine receptor affinity by multivalency

ACS Chemical Biology, 2014
Gephyrin is a major determinant for the accumulation and anchoring of glycine receptors (GlyRs) and the majority of γ-aminobutyric acid type A receptors (GABAARs) at postsynaptic sites.
Kasaragod, Vikram Babu, Schindelin, Hermann, Maric, Hans-Michael   +2 more
core   +4 more sources

Fast and reversible trapping of surface glycine receptors by gephyrin

Nature Neuroscience, 2001
Variations in receptor number at a given synapse are known to contribute to synaptic plasticity, but methods used to establish this idea usually do not allow for the determination of the dynamics of these phenomena.
Choquet, D., A. Triller, Meier, J., A. Sergé, Vannier, C., D. Choquet, Serge, A., Triller, A., J. Meier, C. Vannier   +9 more
core   +3 more sources

Biphasic Memory Impairment and Recovery After Sevoflurane Exposure Are Associated With Time-Dependent Hippocampal α5-GABAAR Remodeling. [PDF]

CNS Neurosci Ther
Our study reveals that the reversible changes in memory impairment and recovery following sevoflurane with dynamic changes of expression and distribution of α5‐GABAAR. Memory impairment is associated with the upregulation of α5‐GABAAR expression and postsynaptic distribution on day 2 after sevoflurane exposure.
Wang S, Chen L, Wang S, Zhang C, Zhang M, Wang Z, Dong J, Liu Q, Dong Z, Wang X, Dong Y, Luo Y, Wang Y, Yin Y.   +13 more
europepmc   +2 more sources

Lewy Bodies Are Not Associated With Neuronal or Synaptic Loss in Dementia With Lewy Bodies. [PDF]

Neuropathol Appl Neurobiol
Lewy bodies are thought to be central drivers of neurodegeneration and synaptic loss in dementia with Lewy bodies (DLB). In this article, Hawksworth, Kirkby‐Geddes et al. observe no associations between Lewy body density and loss of neurons or synaptic markers in DLB.
Hawksworth JI, Kirkby-Geddes E, Thom S, O'Neill J, Ikwue A, Wood L, Outeiro TF, Erskine D.   +7 more
europepmc   +2 more sources