Postsynaptic density radiation signature following space irradiation [PDF]
Frontiers in Physiology, 2023 Introduction: The response of the brain to space radiation is an important concern for astronauts during space missions. Therefore, we assessed the response of the brain to 28Si ion irradiation (600 MeV/n), a heavy ion present in the space environment ...
Soren Impey +12 more
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Phase separation-mediated actin bundling by the postsynaptic density condensates [PDF]
eLife, 2023 The volume and the electric strength of an excitatory synapse is near linearly correlated with the area of its postsynaptic density (PSD). Extensive research in the past has revealed that the PSD assembly directly communicates with actin cytoskeleton in ...
Xudong Chen +3 more
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Dysregulated Signaling at Postsynaptic Density: A Systematic Review and Translational Appraisal for the Pathophysiology, Clinics, and Antipsychotics’ Treatment of Schizophrenia [PDF]
Cells, 2023 Emerging evidence from genomics, post-mortem, and preclinical studies point to a potential dysregulation of molecular signaling at postsynaptic density (PSD) in schizophrenia pathophysiology. The PSD that identifies the archetypal asymmetric synapse is a
Andrea de Bartolomeis +5 more
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Reconstitution of Membrane-tethered Postsynaptic Density Condensates Using Supported Lipid Bilayer [PDF]
Bio-Protocol, 2023 Eukaryotic cells utilize sub-cellular compartmentalization to restrict reaction components within a defined localization to perform specified biological functions.
Zhe Feng, Mingjie Zhang
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Multivalent Tau/PSD-95 interactions arrest in vitro condensates and clusters mimicking the postsynaptic density [PDF]
Nature Communications, 2023 Alzheimer’s disease begins with mild memory loss and slowly destroys memory and thinking. Cognitive impairment in Alzheimer’s disease has been associated with the localization of the microtubule-associated protein Tau at the postsynapse.
Zheng Shen +7 more
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Cryo-EM tomography and automatic segmentation delineate modular structures in the postsynaptic density [PDF]
Frontiers in Synaptic Neuroscience, 2023 Postsynaptic densities (PSDs) are large protein complexes associated with the postsynaptic membrane of excitatory synapses important for synaptic function including plasticity.
Jae Hoon Jung +2 more
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Non-microtubule tubulin-based backbone and subordinate components of postsynaptic density lattices [PDF]
Life Science Alliance, 2021 This study proposes a postsynaptic density (PSD) lattice model comprising a non-microtubule tubulin-based backbone structure and its associated proteins, including various PSD scaffold/adaptor proteins and other PSD proteins.
Tatsuo Suzuki +8 more
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PKC and PKA regulate AChR dynamics at the neuromuscular junction of living mice. [PDF]
PLoS ONE, 2013 The steady state of the acetylcholine receptor (AChR) density at the neuromuscular junction (NMJ) is critical for efficient and reliable synaptic transmission.
Isabel Martinez-Pena y Valenzuela +2 more
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PLoS ONE, 2012 Direct comparison of protein components from human and mouse excitatory synapses is important for determining the suitability of mice as models of human brain disease and to understand the evolution of the mammalian brain.
Alex Bayés +5 more
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Frontiers in Molecular Neuroscience, 2022 Actin filaments form the backbone of dendritic spines, the postsynaptic compartment of most excitatory synapses in the brain. Spine density changes affect brain function, and postsynaptic actin defects have been implicated in various neuropathies.
A. Özge Sungur +12 more
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