Results 11 to 20 of about 82,465 (254)
The postsynaptic density: there is more than meets the eye [PDF]
Frontiers in Synaptic Neuroscience, 2016 The postsynaptic density (PSD), apparent in electron micrographs as a dense lamina just beneath the postsynaptic membrane, includes a deeper layer, the pallium, containing a scaffold of Shank and Homer proteins.
Ayse Dosemeci +3 more
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Mesophasic Assembly of Inhibitory Postsynaptic Density. [PDF]
Neurosci Bull, 2021 Bai G, Zhang M.
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The postsynaptic density [PDF]
Current Biology, 2009 What is the postsynaptic density (PSD)? Seen by electron microscopy (EM) as an electron-dense thickening of the postsynaptic membrane of excitatory synapses, the PSD contains a high concentration of structural and signaling proteins connected physically and functionally to postsynaptic glutamate receptors and transsynaptic adhesion molecules.
Kim, E Kim, Eunjoon +1 more
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PROTEINS OF THE POSTSYNAPTIC DENSITY [PDF]
The Journal of Cell Biology, 1974 An analysis was made of the protein composition of a fraction of postsynaptic densities (PSDs) prepared from rat brain. Protein makes up 90% of the material in the PSD fraction. Two major polypeptide fractions are present, based on sodium dodecyl sulfate polyacrylamide gel electrophoresis. The major polypeptide fraction has a molecular weight of 53,000,
Banker, G, Churchill, L, Cotman, CW
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Postsynaptic density antigens: preparation and characterization of an antiserum against postsynaptic densities [PDF]
The Journal of Cell Biology, 1981 Long-term immunization of rabbits with postsynaptic densities (PSD) from bovine brain produced an antiserum specific for PSD as judged by binding to subcellular fractions and immunohistochemical location at the light and electron microscope levels. (a) The major antigens of bovine PSD preparations were three polypeptides of molecular weight 95,000 (PSD-
Sampedro, MN, Bussineau, CM, Cotman, CW
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Lateral organization of the postsynaptic density [PDF]
Molecular and Cellular Neuroscience, 2011 Fast excitatory synaptic transmission is mediated by AMPA-type glutamate receptors (AMPARs). It is widely accepted that the number of AMPARs in the postsynaptic density (PSD) critically determines the efficiency of synaptic transmission, but an unappreciated aspect of synapse organization is the lateral positioning of AMPARs within the PSD, that is ...
Harold D, MacGillavry +2 more
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IRSp53 accumulates at the postsynaptic density under excitatory conditions. [PDF]
PLoS ONE, 2017 IRSp53 (BAIAP2) is an abundant protein at the postsynaptic density (PSD) that binds to major PSD scaffolds, PSD-95 and Shanks, as well as to F-actin.
Ayse Dosemeci +4 more
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Frontiers in Molecular Neuroscience, 2022 Chronic Postsurgical Pain (CPSP) is well recognized to impair cognition, particularly memory. Mounting evidence suggests anatomic and mechanistic overlap between pain and cognition on several levels.
Zhen Li +5 more
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Enlightening the Postsynaptic Density [PDF]
Neuron, 1997 Research on the PSD touches many branches of neuroscience, and I regret that many relevant studies could not be cited for lack of space. I thank Drs. Nancy Desmond, Lucas Pozzo-Miller, Dennis Landis, James Gurd, and Philip Gordon-Weaks for provision of photographs of the PSD, Dr. R. MacKinnon for PDZ domain structure coordinates, and Drs.
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Organization of the core structure of the postsynaptic density [PDF]
Proceedings of the National Academy of Sciences, 2008 Much is known about the composition and function of the postsynaptic density (PSD), but less is known about its molecular organization. We use EM tomography to delineate the organization of PSDs at glutamatergic synapses in rat hippocampal cultures. The core of the PSD is dominated by vertically oriented filaments, and ImmunoGold labeling shows that ...
Xiaobing, Chen +6 more
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