Results 21 to 30 of about 82,465 (254)
The DLGAP family: neuronal expression, function and role in brain disorders
Molecular Brain, 2017 The neurotransmitter glutamate facilitates neuronal signalling at excitatory synapses. Glutamate is released from the presynaptic membrane into the synaptic cleft.
Andreas H. Rasmussen +2 more
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eLife, 2017 Synapse formation and growth are tightly controlled processes. How synaptic growth is terminated after reaching proper size remains unclear. Here, we show that Leon, the Drosophila USP5 deubiquitinase, controls postsynaptic growth.
Chien-Hsiang Wang +6 more
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Identification and Investigation of Postsynaptic Density Homologs
Bioinformatics and Biology Insights, 2008 AMPA receptors are responsible for fast excitatory transmission in the CNS and the trafficking of these receptors has been implicated in LTP and learning and memory. These receptors reside in the postsynaptic density, a network of proteins that links the
Faith L.W. Liebl, David E. Featherstone
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Entropy, 2019 The human postsynaptic density is an elaborate network comprising thousands of proteins, playing a vital role in the molecular events of learning and the formation of memory.
Annamária Kiss-Tóth +6 more
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Phosphorylation state of postsynaptic density proteins [PDF]
Journal of Neurochemistry, 2005 AbstractThe postsynaptic density (PSD) is an electron‐dense structure located at the synaptic contacts between neurons. Its considerable complexity includes cytoskeletal and scaffold proteins, receptors, ion channels and signaling molecules, in line with the role of PSDs in signal transduction and processing.
J C, Trinidad +4 more
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Maturation of Heterogeneity in Afferent Synapse Ultrastructure in the Mouse Cochlea
Frontiers in Synaptic Neuroscience, 2021 Auditory nerve fibers (ANFs) innervating the same inner hair cell (IHC) may have identical frequency tuning but different sound response properties. In cat and guinea pig, ANF response properties correlate with afferent synapse morphology and position on
Shelby A. Payne +22 more
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Differential distribution of Shank and GKAP at the postsynaptic density. [PDF]
PLoS ONE, 2015 Shank and GKAP are scaffold proteins and binding partners at the postsynaptic density (PSD). The distribution and dynamics of Shank and GKAP were studied in dissociated hippocampal cultures by pre-embedding immunogold electron microscopy.
Jung-Hwa Tao-Cheng +3 more
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Function of a calmodulin in postsynaptic densities. III. Calmodulin-binding proteins of the postsynaptic density. [PDF]
The Journal of cell biology, 1981 A method has been developed for binding calmodulin, radioiodinated by the lactoperoxidase method, to denaturing gels and has been used to attempt to identify the calmodulin-binding proteins of cerebral cortex postsynaptic densities (PSDs). Calmodulin primarily bound to the major 51,000 Mr protein in a saturatable manner; secondarily bound to the 60,000
R K, Carlin, D J, Grab, P, Siekevitz
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Frontiers in Molecular Neuroscience, 2022 Genetic variations resulting in the loss of function of the discs large homologs (DLG2)/postsynaptic density protein-93 (PSD-93) gene have been implicated in the increased risk for schizophrenia, intellectual disability, and autism spectrum disorders ...
Taesun Yoo +9 more
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Postsynaptic Targeting of Alternative Postsynaptic Density-95 Isoforms by Distinct Mechanisms [PDF]
The Journal of Neuroscience, 2002 Members of the postsynaptic density-95 (PSD95)/synapse-associated protein-90 (SAP90) family of scaffolding proteins contain a common set of modular protein interaction motifs including PDZ (postsynaptic density-95/Discs large/zona occludens-1), Src homology 3, and guanylate kinase domains, which regulate signaling and plasticity at excitatory synapses.
Dane M, Chetkovich +5 more
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