Results 31 to 40 of about 82,465 (254)
DHA-dominant Omega-3 compositions enhance PSD-95 organization and glutamatergic protein expression
Frontiers in Synaptic NeuroscienceIntroductionDocosahexaenoic acid (DHA), the predominant omega-3 (ω-3) fatty acid in the brain, which contributes to synaptic membrane organization and plasticity, is commonly recommended for brain health.
Gerardo Medina +5 more
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Molecular Systems Biology, 2009 The molecular complexity of mammalian proteomes demands new methods for mapping the organization of multiprotein complexes. Here, we combine mouse genetics and proteomics to characterize synapse protein complexes and interaction networks.
Esperanza Fernández +9 more
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Kalirin-7 is a Key Player in the Formation of Excitatory Synapses in Hippocampal Neurons
The Scientific World Journal, 2010 Kalirin-7 (Kal7), a major isoform of Kalirin in the adult rodent hippocampus, is exclusively localized to the postsynaptic side of mature excitatory synapses in hippocampal neurons.
Xin-Ming Ma
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PLoS ONE, 2015 Vertebrate organisms adapt to a continuously changing environment by regulating the strength of synaptic connections between brain cells. Excitatory synapses are believed to increase their strength by vesicular insertion of transmitter glutamate ...
Suleman Hussain, Svend Davanger
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Hippocampal Regulation of Postsynaptic Density Homer1 by Associative Learning
Neural Plasticity, 2017 Genes involved in synaptic plasticity, particularly genes encoding postsynaptic density proteins, have been recurrently linked to psychiatric disorders including schizophrenia and autism.
Nicholas E. Clifton +5 more
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Role of Palmitoylation of Postsynaptic Proteins in Promoting Synaptic Plasticity
Frontiers in Molecular Neuroscience, 2019 Many postsynaptic proteins undergo palmitoylation, the reversible attachment of the fatty acid palmitate to cysteine residues, which influences trafficking, localization, and protein interaction dynamics.
Lucas Matt +3 more
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Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias +3 more
wiley +1 more source
Versatile Endogenous Editing of GluRIIA in Drosophila melanogaster
CellsGlutamate receptors at the postsynaptic side translate neurotransmitter release from presynapses into postsynaptic excitation. They play a role in many forms of synaptic plasticity, e.g., homeostatic scaling of the receptor field, activity-dependent ...
Constantin J. Beckers +3 more
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Zinc Stabilizes Shank3 at the Postsynaptic Density of Hippocampal Synapses. [PDF]
PLoS ONE, 2016 Shank3 is a postsynaptic density (PSD) scaffold protein of the Shank family. Here we use pre-embedding immunogold electron microscopy to investigate factors influencing the distribution of Shank3 at the PSD.
Jung-Hwa Tao-Cheng +4 more
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Electrophysiology and plasticity in isolated postsynaptic densities
Brain Research Reviews, 2004 The organization and regulation of excitatory synapses in the mammalian CNS entails complex molecular and cellular processes. In the postsynaptic membrane, scaffolding proteins bring together glutamate receptors with multiple regulatory proteins involved in signal transduction.
Wyneken, Ursula +2 more
openaire +4 more sources