Results 1 to 10 of about 2,578,136 (352)
DJ-1 associates with synaptic membranes
Neurobiology of Disease, 2011 Parkinson's disease (PD) is a neurodegenerative disorder caused by loss of dopaminergic neurons. Although many reports have suggested that genetic factors are implicated in the pathogenesis of PD, molecular mechanisms underlying selective dopaminergic ...
Yukiko Usami +14 more
doaj +4 more sources
Microtransplantation of Synaptic Membranes to Reactivate Human Synaptic Receptors for Functional Studies. [PDF]
J Vis Exp, 2022 Excitatory and inhibitory ionotropic receptors are the major gates of ion fluxes that determine the activity of synapses during physiological neuronal communication. Therefore, alterations in their abundance, function, and relationships with other synaptic elements have been observed as a major correlate of alterations in brain function and cognitive ...
Miller B +3 more
europepmc +3 more sources
Dephosphorylation of B-50 in synaptic plasma membranes [PDF]
Brain Research Bulletin, 1990 Synaptic plasma membranes from rat brain cortex possess intrinsic ability to dephosphorylate the endogenous protein B-50. At low concentrations of [gamma-32P]ATP, B-50 phosphorylation in synaptic membranes is maximal at 30 seconds, followed by dephosphorylation for an additional 60 minutes.
Linda A Dokas +2 more
exaly +4 more sources
A novel synaptic junction preparation for the identification and characterization of cleft proteins. [PDF]
PLoS ONE, 2017 Identification of synaptic cleft components has been hampered by the lack of a suitable preparation enriched in synaptic junctions devoid of adjoining peripheral membranes.
Amelia Burch +2 more
doaj +1 more source
Modification of the synaptic cleft under excitatory conditions
Frontiers in Synaptic Neuroscience, 2023 The synaptic cleft is the extracellular part of the synapse, bridging the pre- and postsynaptic membranes. The geometry and molecular organization of the cleft is gaining increased attention as an important determinant of synaptic efficacy.
Jung-Hwa Tao-Cheng +4 more
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An electrostatically preferred lateral orientation of SNARE complex suggests novel mechanisms for driving membrane fusion. [PDF]
PLoS ONE, 2010 Biological membrane fusion is a basic cellular process catalyzed by SNARE proteins and additional auxiliary factors. Yet, the critical mechanistic details of SNARE-catalyzed membrane fusion are poorly understood, especially during rapid synaptic ...
Ting Guo, Lin-Chen Gong, Sen-Fang Sui
doaj +1 more source
The Nanoscopic Organization of Synapse Structures: A Common Basis for Cell Communication
Membranes, 2021 Synapse structures, including neuronal and immunological synapses, can be seen as the plasma membrane contact sites between two individual cells where information is transmitted from one cell to the other. The distance between the two plasma membranes is
Xiaojuan Yang, Wim Annaert
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Synaptic localization of SAPAP1, a synaptic membrane‐associated protein [PDF]
Genes to Cells, 2003 AbstractBackground: SAPAP1 was originally identified as a protein interacting with the guanylate kinase domain of PSD‐95. SAPAP1 also interacts with various proteins, including neurofilaments, synaptic scaffolding molecule (S‐SCAM), nArgBP2, dynein light chain and Shank through different regions.Results: We expressed various regions of SAPAP1 in ...
Ikuko, Yao +3 more
openaire +2 more sources
Frontiers in Synaptic Neuroscience, 2021 Dysfunction at synapses is thought to be an early change contributing to cognitive, psychiatric and motor disturbances in Huntington’s disease (HD).
Maria Iuliano +7 more
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Frontiers in Cellular Neuroscience, 2020 Proper transport of the Parkinson’s disease (PD) protein, α-synuclein (α-syn), is thought to be crucial for its localization and function at the synapse.
Eric N. Anderson +4 more
doaj +1 more source