Results 21 to 30 of about 2,578,136 (352)
Journal of Lipid Research, 2004 The effects of long-term carnitine supplementation on age-related changes in tissue carnitine levels and in lipid metabolism were investigated. The total carnitine levels in heart, skeletal muscle, cerebral cortex, and hippocampus were ∼20% less in aged ...
Yasukazu Tanaka +7 more
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A synaptic nidogen: developmental regulation and role of nidogen-2 at the neuromuscular junction [PDF]
, 2008 Background: The skeletal neuromuscular junction is a useful model for elucidating mechanisms that regulate synaptogenesis. Developmentally important intercellular interactions at the neuromuscular junction are mediated by the synaptic portion of a basal ...
Fox Michael A +12 more
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The Membrane Interaction of Alpha-Synuclein
Frontiers in Cellular Neuroscience, 2021 A presynaptic protein closely related to Parkinson's disease (PD), α-synuclein (α-Syn), has been studied extensively regarding its pathogenic mechanisms.
Cencen Liu +7 more
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Synaptic shot noise and conductance fluctuations affect the membrane voltage with equal significance [PDF]
, 2005 The subthresholdmembranevoltage of a neuron in active cortical tissue is a fluctuating quantity with a distribution that reflects the firing statistics of the presynaptic population.
Wulfram Gerstner +5 more
core +1 more source
eLife, 2016 Neurotransmitter is released at synapses by fusion of synaptic vesicles with the plasma membrane. To sustain synaptic transmission, compensatory retrieval of membranes and vesicular proteins is essential.
Yuji Okamoto +6 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Mammalian brain circuits are wired by dynamic formation and remodeling during development to produce a balance of excitatory and inhibitory synapses. Synaptic regulation is mediated by a complex network of proteins including immunoglobulin (Ig)- class ...
Bryce W. Duncan +2 more
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Agrin binds to the nerve-muscle basal lamina via laminin. [PDF]
, 1997 Agrin is a heparan sulfate proteoglycan that is required for the formation and maintenance of neuromuscular junctions. During development, agrin is secreted from motor neurons to trigger the local aggregation of acetylcholine receptors (AChRs) and other ...
Brandenberger, R +14 more
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Dual-Function Exocytosis Regulator Has Yet Another Job. [PDF]
PLoS Biology, 2015 A new study shows that synaptotagmins, known to regulate the fusion of neurotransmitter vesicles with synaptic membranes, are also needed for the prior tethering and priming of vesicles. Read the Research Article.
Richard Robinson
doaj +1 more source
Cholesterol asymmetry in synaptic plasma membranes [PDF]
Journal of Neurochemistry, 2011 J. Neurochem.(2011)116, 684–689.AbstractLipids are essential for the structural and functional integrity of membranes. Membrane lipids are not randomly distributed but are localized in different domains. A common characteristic of these membrane domains is their association with cholesterol. Lipid rafts and caveolae are examples of cholesterol enriched
W Gibson, Wood +3 more
openaire +2 more sources
Membrane bridging by Munc13-1 is crucial for neurotransmitter release
eLife, 2019 Munc13-1 plays a crucial role in neurotransmitter release. We recently proposed that the C-terminal region encompassing the C1, C2B, MUN and C2C domains of Munc13-1 (C1C2BMUNC2C) bridges the synaptic vesicle and plasma membranes through interactions ...
Bradley Quade +9 more
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