Results 31 to 40 of about 2,578,136 (352)

Aberrant location of inhibitory synaptic marker proteins in the hippocampus of dystrophin-deficient mice [PDF]

, 2014
Duchenne muscular dystrophy (DMD) is a neuromuscular disease that arises from mutations in the dystrophin-encoding gene. Apart from muscle pathology, cognitive impairment, primarily of developmental origin, is also a significant component of the disorder.
Zablocki, Krzysztof, Elżbieta Krasowska, Krasowska Elżbieta, Gorecki, Dariusz C., Swinny, Jerome D., Dariusz C Górecki, Swinny Jerome D., Zabłocki Krzysztof, Jerome D Swinny, Krasowska, Elzbieta, Górecki Dariusz C., Krzysztof Zabłocki   +11 more
core   +1 more source

A high affinity RIM-binding protein/Aplip1 interaction prevents the formation of ectopic axonal active zones

eLife, 2015
Synaptic vesicles (SVs) fuse at active zones (AZs) covered by a protein scaffold, at Drosophila synapses comprised of ELKS family member Bruchpilot (BRP) and RIM-binding protein (RBP).
Matthias Siebert, Mathias A Böhme, Jan H Driller, Husam Babikir, Malou M Mampell, Ulises Rey, Niraja Ramesh, Tanja Matkovic, Nicole Holton, Suneel Reddy-Alla, Fabian Göttfert, Dirk Kamin, Christine Quentin, Susan Klinedinst, Till FM Andlauer, Stefan W Hell, Catherine A Collins, Markus C Wahl, Bernhard Loll, Stephan J Sigrist   +19 more
doaj   +1 more source

Neuronal SNARE complex assembly guided by Munc18‐1 and Munc13‐1

FEBS Open Bio, 2022
Neurotransmitter release by Ca2+‐triggered synaptic vesicle exocytosis is essential for information transmission in the nervous system. The soluble N‐ethylmaleimide sensitive factor attachment protein receptors (SNAREs) syntaxin‐1, SNAP‐25, and ...
Shen Wang, Cong Ma
doaj   +1 more source

Fibrillization of 40-residue β-Amyloid Peptides in Membrane-Like Environments Leads to Different Fibril Structures and Reduced Molecular Polymorphisms

Biomolecules, 2020
The molecular-level polymorphism in β-Amyloid (Aβ) fibrils have recently been considered as a pathologically relevant factor in Alzheimer’s disease (AD).
Qinghui Cheng, Zhi-Wen Hu, Yuto Tobin-Miyaji, Amy E. Perkins, Terrence Deak, Wei Qiang   +5 more
doaj   +1 more source

Monoiodo-[Trp11]neurotensin, a highly radioactive ligand of neurotensin receptors. Preparation, biological activity, and binding properties to rat brain synaptic membranes.

Journal of Biological Chemistry, 1983
Iodination of [Trp11]neurotensin, a neurotensin analogue in which tyrosine 11 has been substituted by a tryptophan, led to the incorporation of one or two iodine atoms on the single tyrosine residue in position 3.
J. Mazella, C. Poustis, C. Labbe, F. Checler, P. Kitabgi, C. Granier, J. V. Rietschoten, J. Vincent   +7 more
semanticscholar   +1 more source

Purification and characterization of a novel neurotensin-degrading peptidase from rat brain synaptic membranes.

Journal of Biological Chemistry, 1986
A peptidase that cleaved neurotensin at the Pro10-Tyr11 peptide bond, leading to the formation of neurotensin-(1-10) and neurotensin-(11-13), was purified nearly to homogeneity from rat brain synaptic membranes. The enzyme appeared to be monomeric with a
F. Checler, J. Vincent, P. Kitabgi
semanticscholar   +1 more source

3',5'-Cyclic Adenosine Monophosphate- and Ca2+-Calmodulin-Dependent Endogenous Protein Phosphorylation Activity in Membranes of the Bovine Chromaffin Secretory Vesicles: Identification of Two Phosphorylated Components as Tyrosine Hydroxylase and Protein Kinase Regulatory Subunit Type II [PDF]

, 1983
: Membranes of the secretory vesicles from bovine adrenal medulla were investigated for the presence of the endogenous protein phosphorylation activity. Seven phosphoprotein bands in the molecular weight range of 250,000 to 30,000 were observed by means ...
Weber, W., Treiman, M., Gratzl, Manfred
core   +1 more source

Plastic reorganization of hippocampal synapses resulted from pharmacological blockade of type 1 cannabinoid receptors

Анналы клинической и экспериментальной неврологии, 2007
Endogenous cannabinoid system plays an important physiologicalrole in brain functioning, being related to regulation of neuromediatorprocesses and mechanisms of neuroplasticity.Cannabinoid receptors of type 1 (CB1) represent one of the keyelements of ...
L. E. Frumkina, M. Yu. Bobrov, A. A. Lyzhin, E. L. Andrianova, S. K. Koroleva, N. A. Bobrova, L. G. Khaspekov   +6 more
doaj   +1 more source

Sleep Deprivation in Rats Causes Dissociation of the Synaptic NMDA Receptor/D1 Dopamine Receptor Heterocomplex

NeuroSci
Glutamate and dopamine receptors play a crucial role in regulating synaptic plasticity throughout the sleep–wake cycle. These receptors form various heterocomplexes in synaptic areas; however, the role of this protein interactome in sleep–wake cycles ...
Natalia Kiknadze, Nana Narmania, Maia Sepashvili, Tamar Barbakadze, Elene Zhuravliova, Tamar Shetekauri, Nino Tkemaladze, Nikoloz Oniani, David Mikeladze   +8 more
doaj   +1 more source

Synaptic aging disrupts synaptic morphology and function in cerebellar Purkinje cells

Neural Regeneration Research, 2018
Synapses are key structures in neural networks, and are involved in learning and memory in the central nervous system. Investigating synaptogenesis and synaptic aging is important in understanding neural development and neural degeneration in diseases ...
Wen-Juan Fan, Ming-Chao Yan, Lai Wang, Yi-Zheng Sun, Jin-Bo Deng, Jie-Xin Deng   +5 more
doaj   +1 more source