Results 1 to 10 of about 12,720 (163)
Synaptosomes: A Functional Tool for Studying Neuroinflammation
Encyclopedia, 2023 Synaptosomes are subcellular components isolated from nerve terminations that can be prepared by homogenizing brain tissue in isotonic sucrose solution followed by appropriate centrifugation.
Hanna Trebesova +2 more
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Cryo-correlative light and electron tomography of dopaminergic axonal varicosities reveals non-synaptic modulation of cortico-striatal synapses [PDF]
Nature CommunicationsDopamine is an essential neuromodulator in the brain, involved in reward and motor control. Dopaminergic (DA) neurons project to most brain areas, with particularly dense innervation in the striatum.
Paul Lapios +7 more
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Glycine Release Is Upregulated by Metabotropic Glutamate Receptor 1 in Mouse Hippocampus [PDF]
BiomedicinesBackground/Objectives: The neurotransmitter glycine is involved in several physiological and pathological conditions in the Central Nervous System. Different biological structures, including glycine receptors and transporters, are under study as targets ...
Luca Raiteri +3 more
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Prenatal modulation of NADPH-oxidase reverses the deranged GABA switch and rescues behavioral deficits in valproate ASD rat model [PDF]
Frontiers in PharmacologyIndroductionImpaired depolarizing-to-hyperpolarizing (D/H) switch of gamma-aminobutyric acid (GABA) is reported during brain development in rodent valproate-model of autism spectrum disorder (VPA-ASD).
Basma A. Yasseen +23 more
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Studia Universitatis Babes-Bolyai Chemia, 2021 Raman microspectroscopy was tested as an alternative/complementary method for biochemical evaluation of the synaptosomes obtained from neonatal rat brain prenatally exposed to sodium valproate and treated with allicin.
Vlad-Alexandru TOMA +5 more
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Synaptosomes: new vesicles for neuronal mitochondrial transplantation
Journal of Nanobiotechnology, 2021 Background Mitochondrial dysfunction is a critical factor in the onset and progression of neurodegenerative diseases. Recently, mitochondrial transplantation has been advised as an innovative and attractive strategy to transfer and replace damaged ...
Pasquale Picone +7 more
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Scientific Reports, 2021 Synaptosomes are subcellular fractions prepared from brain tissues that are enriched in synaptic terminals, widely used for the study of neural transmission and synaptic dysfunction.
Ushashi Bhattacharya +7 more
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Frontiers in Immunology, 2021 Antibodies recognizing the amino-terminal domain of receptor subunit proteins modify the receptor efficiency to controlling transmitter release in isolated nerve endings (e.g., synaptosomes) indirectly confirming their presence in these particles but ...
Francesca Cisani +11 more
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Chemical Stimulation of Rodent and Human Cortical Synaptosomes: Implications in Neurodegeneration
Cells, 2021 Synaptic plasticity events, including long-term potentiation (LTP), are often regarded as correlates of brain functions of memory and cognition. One of the central players in these plasticity-related phenomena is the α-amino-3-hydroxy-5-methylisoxazole-4-
Faraz Ahmad +3 more
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Metabolites, 2020 Synaptosomes are isolated nerve terminals that contain synaptic components, including neurotransmitters, metabolites, adhesion/fusion proteins, and nerve terminal receptors.
Brian R. Barnett +7 more
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