Results 41 to 50 of about 29,778 (263)
Cells, 2023 This study provides evidence of the existence of presynaptic inhibitory sphingosine-1-phosphate receptor 1 (S1P1R) and facilitatory S1P3R in cortical nerve endings (synaptosomes) of healthy mice.
Alessandra Roggeri +4 more
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Antioxidants, 2022 Oxidative stress is a key contributing factor in the complex degenerating cascade in Parkinson’s disease. The inhibition of MAO-B affords higher dopamine bioavailability and stops ROS formation.
Neda Anastassova +7 more
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Frontiers in Pharmacology, 2020 High-affinity monoamine transporters are targets for prescribed medications and stimulant drugs of abuse. Therefore, assessing monoamine transporter activity for candidate medications and newly-emerging drugs of abuse provides essential information for ...
Marija Ilic +10 more
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Uptake of dihydromorphine- 3H by synaptosomes [PDF]
Life Sciences, 1971 Abstract Tritium-labeled dihydromorphine (DHM-3H) was accumulated in vitro by the synaptosomal fraction (nerve endings) of rat cerebral cortex. Particles derived from nerve endings by osmotic shock exhibited a higher concentration of DHM- 3H than did other subcellular fractions of brain when the isolated fractions were incubated with the ...
Hug, Carl C. Jr., Oka, T.
openaire +3 more sources
The Niemann-Pick C1 protein in recycling endosomes of presynaptic nerve terminals
Journal of Lipid Research, 2006 Niemann-Pick type C (NPC) disease is a fatal, neurodegenerative disorder caused in 95% of cases by loss of function of NPC1, a ubiquitous endosomal transmembrane protein.
Barbara Karten +3 more
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Frontiers in Synaptic Neuroscience, 2021 In Alzheimer’s disease (AD), Amyloid β (Aβ) impairs synaptic function by inhibiting long-term potentiation (LTP), and by facilitating long-term depression (LTD).
Marta Díaz González +6 more
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EFFECT OF TEMPERATURE AND IONOPHORES ON THE PERMEABILITY OF SYNAPTOSOMES [PDF]
, 1979 Synaptosomes swell rapidly in isosmotic solutions of glycerol or urea, but the swelling in solutions of larger non-electrolytes, such as erythritol, glucose or sucrose is slower.
Carvalho, C. A. M., Carvalho, A. P.
core +1 more source
Biomedicines, 2020 Silymarin, a polyphenoic flavonoid derived from the seeds of milk thistle (Silybum marianum), exhibits neuroprotective effects. In this study, we used a model of rat cerebrocortical synaptosomes to investigate whether silymarin affects the release of ...
Cheng-Wei Lu +5 more
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Cells, 2022 The glutamatergic nerve endings of a rat prefrontal cortex (PFc) possess presynaptic 5-HT2A heteroreceptors and mGlu2/3 autoreceptors, whose activation inhibits glutamate exocytosis, and is measured as 15 mM KCl-evoked [3H]D-aspartate ([3H]D-asp) release
Alice Taddeucci +8 more
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Membranes, 2021 Morphologically and functionally identical to brain synapses, the nerve ending particles synaptosomes are biochemically derived membrane structures responsible for the transmission of neural information.
Virjinia Doltchinkova +2 more
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