Results 61 to 70 of about 29,778 (263)
Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles
Mass Spectrometry Reviews, EarlyView.ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág +5 more
wiley +1 more source
Plasticity of GluN1 at Ventral Hippocampal Synapses in the Infralimbic Cortex
Frontiers in Synaptic Neuroscience, 2021 Although the infralimbic cortex (IL) is not thought to play a role in fear acquisition, recent experiments found evidence that synaptic plasticity is occurring at ventral hippocampal (vHPC) synapses in IL during auditory fear acquisition as measured by ...
Yesenia Castillo-Ocampo +5 more
doaj +1 more source
Neurourology and Urodynamics, EarlyView.ABSTRACT Background & Aims Neurogenic lower urinary tract dysfunction (NLUTD) can produce bothersome urinary symptoms, impact quality of life, and in some cases, lead to deterioration of upper urinary tract function. Intradetrusor injection of onabotulinumtoxin‐A (BoNT‐A) is approved for NLUTD in patients who have an inadequate response to or ...
Shirley L. Wang +2 more
wiley +1 more source
Synaptic NMDAR stimulation induces LTP in synaptosomes.
, 2013 A, Sustained increase in surface AMPAR levels in synaptosomes following KCl and glycine stimulation. Synaptosomes were incubated at 37°C for 20 min. in the presence of glycine (100 µM) followed by depolarization with high KCl (50 mM) for 5–120 min.
Guy Doucet (372199) +2 more
core +1 more source
Sequences of Reverse Transcribed Brain DNA Are Modified by Learning
Frontiers in Molecular Neuroscience, 2020 Brain metabolic DNA (BMD) is continuously synthesized by reverse transcription in presynaptic synaptosomes and astroglia, and is partly transferred to nuclei after acquiring the double stranded configuration.
Antonio Giuditta, Joyce Casalino
doaj +1 more source
PROTEOMICS, EarlyView.ABSTRACT Despite their widespread use as a research model, a comprehensive, quantitative proteomic profile of the cultured hippocampal neurons has remained unexplored. Here, we provide the first global proteomic characterization of primary murine hippocampal neurons cultured for 14 days under near‐physiological glucose conditions (2.5 mM).
Dominika Drulis‐Fajdasz +6 more
wiley +1 more source
Model of LTP and AMPA-mediated depotentiation in synaptosomes.
, 2013 Synaptic NMDAR stimulation, High KCl concentration depolarizes synaptosomes releasing endogenous glutamate, which activates synaptic NMDARs in conjunction with the NMDAR co-agonist glycine.
Guy Doucet (372199) +2 more
core +1 more source
Neurobiology of Disease, 2019 In fragile X syndrome, the absence of Fragile X Mental Retardation Protein (FMRP) is known to alter postsynaptic function, although alterations in presynaptic function also occur.
Nuria García-Font +4 more
doaj +1 more source
Molecules, 2023 Inhibiting the excessive release of glutamate in the brain is emerging as a promising therapeutic option and is efficient for treating neurodegenerative disorders.
Kuan-Ming Chiu +4 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose The pathogenesis of type 2 diabetes mellitus (T2DM)‐induced cardiomyopathy involves cardiac fibrosis that leads to diastolic dysfunction. We established that replacement of lost substance P (SP) that occurs in T2DM reduces cardiac fibrosis and decreases inflammation in T2DM mice and non‐human primates.
Alexander Widiapradja +11 more
wiley +1 more source