Results 71 to 80 of about 29,778 (263)
Proteasome function is required for AMPA-induced depotentiation of synaptosomes.
, 2013 A, Proteasome inhibitors block AMPA-induced AMPAR internalization after LTP in synaptosomes. LTP was induced in synaptosomes and AP5 (100 µM) was added as in figure 2F.
Guy Doucet (372199) +2 more
core +1 more source
Headache: The Journal of Head and Face Pain, EarlyView.Abstract Background Calcitonin gene‐related peptide (CGRP) is a key mediator in migraine pathophysiology, and the development of gepants, novel CGRP receptor antagonists, has expanded therapeutic options for both acute and preventive treatment. This scoping review aims to synthesize current evidence on the pharmacology, clinical applications, safety ...
Luigi Francesco Iannone +5 more
wiley +1 more source
Single synaptosomes transcriptomics analysis.
, 2022 Synapses are an essential part of neuronal communication. Studies of isolated synapses, otherwise known as synaptosomes, have revealed about selective transcript enrichment in synaptosomes from bulk sample analysis.
Rukšnaitytė, Greta,
core
FEBS Letters, Volume 600, Issue 12, Page 1770-1781, June 2026.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
Pyruvate utilization by synaptosomes is independent of calcium
, 1986 The significance of Ca2+ is assessed for the activation of pyruvate oxidation by intact nerve terminals (synaptosomes). Titration of glucose-depleted synaptosomes with pyruvate in the presence of either veratridine or uncoupler stimulates respiration in ...
Risto A. Kauppinen +3 more
core +1 more source
ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology
Advanced Science, Volume 13, Issue 32, 9 June 2026.This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li +25 more
wiley +1 more source
Synaptosomes as a Platform for Loading Nanoparticles into Synaptic Vesicles
, 2016 Synaptosomes are intact, isolated nerve terminals that contain the necessary machinery to recycle synaptic vesicles via endocytosis and exocytosis upon stimulation.
Noah G. Shuart (2199268) +7 more
core +1 more source
Neuron, 2015 Summary The functional and molecular similarities and distinctions between human and murine astrocytes are poorly understood. Here we report the development of an immunopanning method to acutely purify astrocytes from fetal, juvenile, and adult human ...
Ye Zhang +16 more
semanticscholar +1 more source
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract BACKGROUND APPE693Q (“Dutch”) transgenic mice develop aging‐related learning deficits and accumulate endogenously generated non‐fibrillar aggregates (NFAs) of amyloid beta (Aβ) and amyloid precursor protein α‐carboxy terminal fragments. NFA‐Aβ correlates with synaptic loss and memory deficits more closely than does fibrillar Aβ.
Emilie L. Castranio +28 more
wiley +1 more source
Silexan dose-dependently inhibits VOCCs in murine synaptosomes.
, 2013 Dose-dependent effects of pregabalin (A), Silexan (B) and linalool (D) on KCl-induced Ca2+-influx. Murine synaptosomes were preincubated (10 min) with different concentrations of pregabalin (A, 0.03–100 µM), Silexan (B, 0.01–10 µg/ml) or linalool (D, 0 ...
Michael Nöldner (408097) +5 more
core +1 more source