Results 81 to 90 of about 29,778 (263)

Physiology, pathology and therapeutic potential of microglial triggering receptor expressed on myeloid cells 2 signalling: A narrative update

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
TREM2hi microglia and macrophages exert distinct roles in neurological diseases. Enhancing TREM2 signalling supports pathological protein or debris clearance and mitigates inflammation in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, demyelination disorders and stroke, whereas blocking TREM2 may alleviate tauopathy and ...
Zhe Kong, Libin Shen, Daqing Ma, Jinchao Hou   +3 more
wiley   +1 more source

Phillygenin Suppresses Glutamate Exocytosis in Rat Cerebrocortical Nerve Terminals (Synaptosomes) through the Inhibition of Ca_v2.2 Calcium Channels

Biomedicines
Glutamate is a major excitatory neurotransmitter that mediates neuronal damage in acute and chronic brain disorders. The effect and mechanism of phillygenin, a natural compound with neuroprotective potential, on glutamate release in isolated nerve ...
Ming-Yi Lee, Tzu-Yu Lin, Ya-Ying Chang, Kuan-Ming Chiu, Su-Jane Wang   +4 more
doaj   +1 more source

Aplysia synaptosomes. II. Release of transmitters

, 1989
A subcellular fraction (P3) from Aplysia is enriched in synaptosomes (Chin et al., 1988) and is capable of accumulating 5-HT and choline. At an external 3H-5-HT concentration of 1.8 microM, the P3 fraction took up 0.12 nmol/mg protein in 30 min.
GJ Chin, JH Schwartz, E Shapiro
core   +1 more source

Intermediate filaments link glutamate–aspartate transporter deficiency to cochlear synaptopathy

The FEBS Journal, Volume 293, Issue 12, Page 3461-3465, June 2026.
In a healthy ear, GLAST transporters in supporting cells clear excess glutamate to protect auditory connections. When GLAST is missing, glutamate accumulates and leads to the destruction of structural scaffolding within the postsynaptic nerve endings. This internal collapse causes a loss of synapses that are essential for hearing, ultimately resulting ...
Paul Emmerich Krumpoeck, Lukas David Landegger   +1 more
wiley   +1 more source

Asymptomatic Versus Symptomatic Alzheimer's Disease Neuropathology: A Systematic Review of Differences Reported in Post‐Mortem Studies

Neuropathology and Applied Neurobiology, Volume 52, Issue 3, June 2026.
Graphical summary of post‐mortem brain tissue findings that differ between symptomatic and asymptomatic AD. Current evidence suggests reduced accumulation of Aβ and p‐tau oligomers, particularly at synapses, preserved neuronal and synaptic integrity and metabolic activity and a dynamic profile of glial and immune responses in ASYMAD.
Thiago Guilherme Rêgo Barros, Laura Barbosa Grossi, Maria Letícia da Silva Campos, Israel Bem‐Hur Netto Cardoso, Antônio Lúcio Teixeira, Aline Silva de Miranda, Eliana Cristina de Brito Toscano   +6 more
wiley   +1 more source

NMDAR cluster modifications in rat hippocampal synaptosomes following calpain activation.

, 2015
(A) Rat hippocampal synaptosomes were incubated at 37°C for 12 min with (NMDA) or without (Control) 100 μM NMDA in HEPES buffer containing 1 μM glycine and 1 mM CaCl2.
Sandro Pontremoli (309270), Monica Averna (164404), Chiara Cervetto (309268), Franca Salamino (309263), Marco Pedrazzi (309260), Margherita Bavestrello (682815), Edon Melloni (164418), Matteo Pellegrini (2078), Roberta De Tullio (365362)   +8 more
core   +1 more source

Protein Kinase C-mediated Phosphorylation and Functional Regulation of Dopamine Transporters in Striatal Synaptosomes*

Journal of Biological Chemistry, 1997
Dopamine transporters (DATs) are members of a family of Na+- and Cl−-dependent neurotransmitter transporters responsible for the rapid clearance of dopamine from synaptic clefts.
R. Vaughan, Robin A. Huff, G. Uhl, M. Kuhar   +3 more
semanticscholar   +1 more source

Microglia Mitochondria Support Neuronal Maturation via Metabolic and Transcriptional Reprogramming in Human 3D In Vitro Brain Model

Advanced Science, Volume 13, Issue 25, 4 May 2026.
xx xx. ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial function and mitochondrial regulation as contributors to ASD‐associated biology, yet the mechanisms linking these processes to neuronal development remain poorly defined ...
Sydney P. Sterben, Charitha C. Anamala, Sahan B. S. Kansakar, Vaishnavi Koduri, Volha Liaudanskaya   +4 more
wiley   +1 more source

Characterization of neocortical and hippocampal synaptosomes from temporal lobe epilepsy patients

, 1999
To investigate epilepsy-associated changes in the presynaptic terminal, we isolated and characterized synaptosomes from biopsies resected during surgical treatment of drug-resistant temporal lobe epilepsy (TLE) patients.
Hoogland, G., Blomenrohr, M., Veelen, C.W. van, Wit, de M., Henk A Spierenburg, Cees W.M van Veelen, Willem Hendrik Gispen, Dijstelbloem, H.M., Govert Hoogland, Hilde Dijstelbloem, Spierenburg, H.A., Rijen, P.C. van, Marion Blomenröhr, Huffelen, A.C. van, Graan, P.N. de, Marina de Wit, Peter C van Rijen, Gispen, W.H., Pierre N.E de Graan, Alexander C van Huffelen   +19 more
core   +1 more source

Pre‐analytical guidelines for blood and CSF Biomarkers 2025: Recommendations from the NACC ADRC Biofluid Biomarker Best Practices Workgroup

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract The Biofluid Biomarkers Best Practices Workgroup of the National Alzheimer's Coordinating Center–Alzheimer's Disease Research Center (ADRC) Biomarker Core Steering Committee was convened to update pre‐analytical handling guidelines for biofluid biomarkers, focusing on cerebrospinal fluid (CSF) and blood.
Timothy E. Van Meter, Edward N. Wilson, Fanny Elahi, Robert A. Rissman, Argentina Lario Lago, Kelley Faber, Kathryn Gauthreaux, Ricardo Osorio, Matthew Perkins, Nora Gray, Jill Morris, Andy Liu, Hannah Stockwell, Walter Kukull, Rachael Wilson, Thomas S. Wingo, Nicholas M. Kanaan, Kristen Russ, Donna Wilcock, Sarah A. Biber, Lynn M. Bekris, Thomas K. Karikari   +21 more
wiley   +1 more source