Results 21 to 30 of about 29,778 (263)

Neuroprotective and antioxidant activities of saponins’ mixture from Astragalus glycyphylloides in a model of 6-hydroxydopamine-induced oxidative stress on isolated rat brain synaptosomes [PDF]

Pharmacia, 2019
The aim of the study was to investigate the possible neuroprotective and antioxidant activity of purified saponins’mixture (PSM), isolated from Astragalus glycyphylloides (Fabaceae), in a model of 6-hydroxydipamine (6-OHDA)-induced oxidative stress on ...
Magdalena Kondeva-Burdina, Ilina Krasteva, Georgi Popov, Vasil Manov   +3 more
doaj   +3 more sources

Newly Synthesized Creatine Derivatives as Potential Neuroprotective and Antioxidant Agents on In Vitro Models of Parkinson’s Disease

Life, 2023
Oxidative stress is one of the key factors responsible for many diseases–neurodegenerative (Parkinson and Alzheimer) diseases, diabetes, atherosclerosis, etc.
Ivanka Kostadinova, Magdalena Kondeva-Burdina, Lyubomir Marinov, Lubomir L. Vezenkov, Rumyana Simeonova   +4 more
doaj   +1 more source

Synaptosome Proteomics [PDF]

, 2007
Our knowledge of the complex synaptic proteome and its relationship to physiological or pathological conditions is rapidly expanding. This has been greatly accelerated by the application of various evolving proteomic techniques, enabling more efficient protein resolution, more accurate protein identification, and more comprehensive characterization of ...
Fengju, Bai, Frank A, Witzmann
openaire   +2 more sources

Subsynaptic Distribution, Lipid Raft Targeting and G Protein-Dependent Signalling of the Type 1 Cannabinoid Receptor in Synaptosomes from the Mouse Hippocampus and Frontal Cortex

Molecules, 2021
Numerous studies have investigated the roles of the type 1 cannabinoid receptor (CB1) in glutamatergic and GABAergic neurons. Here, we used the cell-type-specific CB1 rescue model in mice to gain insight into the organizational principles of plasma ...
Miquel Saumell-Esnaola, Sergio Barrondo, Gontzal García del Caño, María Aranzazu Goicolea, Joan Sallés, Beat Lutz, Krisztina Monory   +6 more
doaj   +1 more source

Unveiling the nongenomic actions of thyroid hormones in adult mammalian brain: The legacy of Mary B. Dratman

Frontiers in Endocrinology, 2023
A comprehensive review was conducted to compile the contributions of Mary B. Dratman and studies by other researchers in the field of nongenomic actions of thyroid hormones in adult mammalian brain.
Nilkanta Chakrabarti, Nilkanta Chakrabarti, Pradip K. Sarkar, Arun K. Ray, Joseph V. Martin   +4 more
doaj   +1 more source

Isolation, cryo-laser scanning confocal microscope imaging and cryo-FIB milling of mouse glutamatergic synaptosomes.

PLoS ONE, 2022
Ionotropic glutamate receptors (iGluRs) at postsynaptic terminals mediate the majority of fast excitatory neurotransmission in response to release of glutamate from the presynaptic terminal.
Prerana Gogoi, Momoko Shiozaki, Eric Gouaux   +2 more
doaj   +1 more source

Increased seizure sensitivity in pregnant mice with genetic knockdown of acid sensing ion channel 2a is associated with impaired hippocampal inflammatory response

Frontiers in Physiology, 2022
Acid sensing ion channels (ASICs) are mechano- and chemo-receptor channels that are activated by drops in extracellular pH as occurs after neurotransmission.
Maria Jones-Muhammad, Qingmei Shao, Junie P. Warrington   +2 more
doaj   +1 more source

The Study of Postmortem Human Synaptosomes for Understanding Alzheimer’s Disease and Other Neurological Disorders: A Review

Neurological Therapeutics, 2017
Synaptic dysfunction is thought to play important roles in the pathophysiology of many neurological diseases, including Alzheimer’s disease, Parkinson’s disease, and schizophrenia.
Jia-Fong Jhou, Hwan‐Ching Tai
semanticscholar   +1 more source

Inhibition of Glutamate Release from Rat Cortical Nerve Terminals by Dehydrocorydaline, an Alkaloid from Corydalis yanhusuo

Molecules, 2022
Excessive release of glutamate induces excitotoxicity and causes neuronal damage in several neurodegenerative diseases. Natural products have emerged as potential neuroprotective agents for preventing and treating neurological disorders ...
Tzu-Yu Lin, I-Yen Chen, Ming-Yi Lee, Cheng-Wei Lu, Kuan-Ming Chiu, Su-Jane Wang   +5 more
doaj   +1 more source

Free radical production and antioxidant status in brain cortex non‐synaptic mitochondria and synaptosomes at alcohol hangover onset

Free Radical Biology & Medicine, 2017
Alcohol hangover (AH) is the pathophysiological state after a binge‐like drinking. We have previously demonstrated that AH induced bioenergetics impairments in a total fresh mitochondrial fraction in brain cortex and cerebellum.
A. Karadayian, G. Malanga, A. Czerniczyniec, Paulina Lombardi, J. Bustamante, S. Lores‐Arnaiz   +5 more
semanticscholar   +1 more source