Results 31 to 40 of about 29,778 (263)

Validation of a System xc– Functional Assay in Cultured Astrocytes and Nervous Tissue Samples

Frontiers in Cellular Neuroscience, 2022
Disruption of the glutamatergic homeostasis is commonly observed in neurological diseases and has been frequently correlated with the altered expression and/or function of astrocytic high-affinity glutamate transporters.
Pauline Beckers, Olaya Lara, Ines Belo do Nascimento, Nathalie Desmet, Ann Massie, Emmanuel Hermans   +5 more
doaj   +1 more source

Conditional Deletion of the Glutamate Transporter GLT-1 Reveals That Astrocytic GLT-1 Protects against Fatal Epilepsy While Neuronal GLT-1 Contributes Significantly to Glutamate Uptake into Synaptosomes

Journal of Neuroscience, 2015
GLT-1 (EAAT2; slc1a2) is the major glutamate transporter in the brain, and is predominantly expressed in astrocytes, but at lower levels also in excitatory terminals.
Geraldine T. Petr, Yan Sun, Natalie M Frederick, Yun Zhou, S. Dhamne, M. Hameed, C. Miranda, Edward Bedoya, Kathryn D. Fischer, W. Armsen, Jianlin Wang, N. Danbolt, A. Rotenberg, C. Aoki, P. Rosenberg   +14 more
semanticscholar   +1 more source

The Depolarization-Evoked, Ca2+-Dependent Release of Exosomes From Mouse Cortical Nerve Endings: New Insights Into Synaptic Transmission

Frontiers in Pharmacology, 2021
Whether exosomes can be actively released from presynaptic nerve terminals is a matter of debate. To address the point, mouse cortical synaptosomes were incubated under basal and depolarizing (25 mM KCl-enriched medium) conditions, and extracellular ...
Guendalina Olivero, Francesca Cisani, Danilo Marimpietri, Daniela Di Paolo, Maria Cristina Gagliani, Marina Podestà, Katia Cortese, Anna Pittaluga, Anna Pittaluga   +8 more
doaj   +1 more source

Evidence for a hydroxy-aluminium polymer (Al13) in synaptosomes

, 1992
The presence of the hydroxy-aluminium polymer (Al13-(OH)24O4(H2O)7+12) was noticed inside synaptosomes when synaptosomes were incubated with Al(NO3)3 at neutral pH values.
K.S.Jagannatha Rao, Rao, K.S.Jagannatha, Gazula Valeswara Rao, Rao, Gazula Valeswara   +3 more
core   +2 more sources

Direct Current-Induced Calcium Trafficking in Different Neuronal Preparations

Neural Plasticity, 2016
The influence of direct current (DC) stimulation on radioactive calcium trafficking in sciatic nerve in vivo and in vitro, spinal cord, and synaptosomes was investigated.
Andrzej Wieraszko, Zaghloul Ahmed
doaj   +1 more source

Preferential accumulation of amyloid-beta in presynaptic glutamatergic terminals (VGluT1 and VGluT2) in Alzheimer's disease cortex

Neurobiology of Disease, 2012
Amyloid-beta (Aβ) is thought to play a central role in synaptic dysfunction (e.g. neurotransmitter release) and synapse loss. Glutamatergic dysfunction is involved in the pathology of Alzheimer's disease (AD) and perhaps plays a central role in age ...
Sophie Sokolow, Sanh H. Luu, Karabi Nandy, Carol A. Miller, Harry V. Vinters, Wayne W. Poon, Karen H. Gylys   +6 more
doaj   +1 more source

Acquisition-dependent modulation of hippocampal neural cell adhesion molecules by associative motor learning

Frontiers in Neuroanatomy, 2022
It is widely accepted that some types of learning involve structural and functional changes of hippocampal synapses. Cell adhesion molecules neural cell adhesion molecule (NCAM), its polysialylated form polysialic acid to NCAM (PSA-NCAM), and L1 are ...
Juan D. Navarro-López, Ana Contreras, Katia Touyarot, Ana I. Herrero, César Venero, Karine Cambon, Agnés Gruart, José M. Delgado-García, Carmen Sandi, Lydia Jiménez-Díaz   +9 more
doaj   +1 more source

Ketamine Rescues Hippocampal Reelin Expression and Synaptic Markers in the Repeated-Corticosterone Chronic Stress Paradigm

Frontiers in Pharmacology, 2020
Depression is the leading cause of disability worldwide, which necessitates novel therapeutics and biomarkers to approach treatment of this neuropsychiatric disorder.
Jenessa N. Johnston, Jonathan S. Thacker, Charissa Desjardins, Brian D. Kulyk, Raquel Romay-Tallon, Lisa E. Kalynchuk, Hector J. Caruncho   +6 more
doaj   +1 more source

Pharmacological Profile of MP-101, a Novel Non-racemic Mixture of R- and S-dimiracetam with Increased Potency in Rat Models of Cognition, Depression and Neuropathic Pain

Cells, 2022
The racemic mixture dimiracetam negatively modulates NMDA-induced glutamate release in rat spinal cord synaptosomal preparations and is orally effective in models of neuropathic pain.
Tiziana Bonifacino, Laura Micheli, Carola Torazza, Carla Ghelardini, Carlo Farina, Giambattista Bonanno, Marco Milanese, Lorenzo Di Cesare Mannelli, Michael W. Scherz   +8 more
doaj   +1 more source

Striatal Synaptosomes from Hdh140Q/140Q Knock-in Mice have Altered Protein Levels, Novel Sites of Methionine Oxidation, and Excess Glutamate Release after Stimulation

Journal of Huntington's Disease, 2013
Background: Synaptic connections are disrupted in patients with Huntington's disease (HD). Synaptosomes from postmortem brain are ideal for synaptic function studies because they are enriched in pre- and post-synaptic proteins important in vesicle fusion,
A. Valencia, E. Sapp, Jeffrey S Kimm, H. McClory, Kwadwo A Ansong, G. Yohrling, S. Kwak, K. Kegel, Karin M. Green, S. Shaffer, N. Aronin, M. Difiglia   +11 more
semanticscholar   +1 more source