Results 11 to 20 of about 2,578,136 (352)

Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal Microautophagy. [PDF]

Neuron, 2015
SummarySynapses are often far from their cell bodies and must largely independently cope with dysfunctional proteins resulting from synaptic activity and stress.
Valerie Uytterhoeven, Elsa Lauwers, Ine Maes, K. Miśkiewicz, M. Melo, J. Swerts, S. Kuenen, Rafaël Wittocx, N. Corthout, S. Marrink, S. Munck, P. Verstreken   +11 more
semanticscholar   +2 more sources

Phospholipids of Synaptic Membranes in the Pathogenesis of Encephalopathy During Hemorrhagic Shock (Review)

Общая реаниматология, 2019
Correction of brain cell damages caused by massive blood loss is one of the urgent problems of hemorrhagic shock, which ensures the need in clarification of mechanisms of such damages with the prospect of developing strategies to restore the functional ...
G. F. Leskova
doaj   +3 more sources

Fusion of synaptic vesicle membranes with planar bilayer membranes

Biophysical Journal, 1989
The interaction of synaptic vesicles with horizontal bilayer lipid membranes (BLMs) was investigated as a model system for neurotransmitter release. High concentrations (200 mM) of the fluorescent dye, calcein, were trapped within synaptic vesicles by freezing and thawing.
Perin, M.S., MacDonald, R.C.
openaire   +3 more sources

Electrokinetic properties of synaptic vesicles and synaptosomal membranes

Biophysical Journal, 1980
Using the technique of electrophoretic light scattering, we have measured the electrophoretic mobilities of synaptic vesicles and synaptosomal plasma membranes isolated from guinea-pig cerebral cortex. The electrophoretic mobility of synaptic vesicles is slightly greater than that of synaptosomal plasma membranes.
Siegel, D.P., Ware, B.R.
openaire   +3 more sources

α-Synuclein interacts directly with AP2 and regulates its binding to synaptic membranes. [PDF]

J Biol Chem
α-Synuclein mutation and aggregation are associated with several neurodegenerative disorders, including Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.
Vargas KJ, Wallace JN, Mooney I, Owen DJ, Morgan JR.   +4 more
europepmc   +2 more sources

Synaptopathies in Developmental and Epileptic Encephalopathies: A Focus on Pre-synaptic Dysfunction

Frontiers in Neurology, 2022
The proper connection between the pre- and post-synaptic nervous cells depends on any element constituting the synapse: the pre- and post-synaptic membranes, the synaptic cleft, and the surrounding glial cells and extracellular matrix.
Giulia Spoto, Giulia Valentini, Maria Concetta Saia, Ambra Butera, Greta Amore, Vincenzo Salpietro, Vincenzo Salpietro, Vincenzo Salpietro, Antonio Gennaro Nicotera, Gabriella Di Rosa   +9 more
doaj   +1 more source

The stimulation by synaptic transmitters of the incorporation of oleate into the phospholipid of synaptic membranes [PDF]

Biochemical Journal, 1975
Noradrenaline stimulated the incorporation of oleate into choline glycerophospholipids of guinea-pig brain synaptic membranes incubated in sodium phosphate buffer. In the presence of 1 mm-NaF, noradrenaline stimulated the incorporation of oleate into the choline glycerophospholipids, phosphatidylinositol, ethanolamine glycerophospholipids ...
R J, Gullis, C E, Rowe
openaire   +2 more sources

Neuromuscular synaptic transmission in aged ganglioside-deficient mice [PDF]

, 2011
Gangliosides are sialylated glycosphingolipids that are present in high density on neuronal membranes, especially at synapses, where they are assumed to play functional or modulating roles.
Todorov, Boyan, Furukawa, Keiko, Furukawa, K., Plomp, J.J., Verschuuren, Jan J., Willison, H.J., Furukawa, Koichi, Plomp, Jaap J., Jacobs, B.C., Todorov, B., Willison, Hugh J., Jacobs, Bart C., Zitman, F.M.P., Verschuuren, J.J., Zitman, Femke M.P.   +14 more
core   +1 more source

Electrical and synaptic integration of glioma into neural circuits

Nature, 2019
High-grade gliomas are lethal brain cancers whose progression is robustly regulated by neuronal activity. Activity-regulated release of growth factors promotes glioma growth, but this alone is insufficient to explain the effect that neuronal activity ...
H. Venkatesh, W. Morishita, Anna C. Geraghty, Dana Silverbush, Shawn M. Gillespie, M. Arzt, L. Tam, Cedric Espenel, Anitha Ponnuswami, Lijun Ni, Pamelyn J. Woo, Kathryn R. Taylor, Amit Agarwal, A. Regev, D. Brang, H. Vogel, S. Hervey-Jumper, D. Bergles, M. Suvà, R. Malenka, Michelle Monje   +20 more
semanticscholar   +1 more source

Neuromuscular synaptic function in mice lacking major subsets of gangliosides [PDF]

, 2008
Gangliosides are a family of sialylated glycosphingolipids enriched in the outer leaflet of neuronal membranes, in particular at synapses. Therefore, they have been hypothesized to play a functional role in synaptic transmission.
Furukawa, K., Plomp, J.J., Willison, H.J., Willison, HJ, Verschuuren, JJ, Todorov, B, Furukawa, K, Jacobs, B.C., Zitman, FMP, Todorov, B., Zitman, F.M.P., Verschuuren, J.J., Plomp, JJ   +12 more
core   +1 more source