Results 31 to 40 of about 5,161 (196)

Neuronal Nitric Oxide Synthase-Dependent S-Nitrosylation of Gephyrin Regulates Gephyrin Clustering at GABAergic Synapses [PDF]

Journal of Neuroscience, 2014
Gephyrin, the principal scaffolding protein at inhibitory synapses, is essential for postsynaptic clustering of glycine and GABA type A receptors (GABA(A)Rs). Gephyrin cluster formation, which determines the strength of GABAergic transmission, is modulated by interaction with signaling proteins and post-translational modifications.
Borislav, Dejanovic, Guenter, Schwarz
openaire   +2 more sources

Modelling and Molecular Dynamics Predict the Structure and Interactions of the Glycine Receptor Intracellular Domain

Biomolecules, 2023
Glycine receptors (GlyRs) are glycine-gated inhibitory pentameric ligand-gated ion channels composed of α or α + β subunits. A number of structures of these proteins have been reported, but to date, these have only revealed details of the extracellular ...
James R. E. Thompson, Christopher A. Beaudoin, Sarah C. R. Lummis   +2 more
doaj   +1 more source

Computational Modeling of Inhibitory Transsynaptic Signaling in Hippocampal and Cortical Neurons Expressing Intrabodies Against Gephyrin

Frontiers in Cellular Neuroscience, 2020
GABAergic transmission regulates neuronal excitability, dendritic integration of synaptic signals and oscillatory activity, thought to be involved in high cognitive functions.
Carmen A. Lupascu, Annunziato Morabito, Federica Ruggeri, Chiara Parisi, Domenico Pimpinella, Rocco Pizzarelli, Giovanni Meli, Silvia Marinelli, Enrico Cherubini, Antonino Cattaneo, Michele Migliore   +10 more
doaj   +1 more source

Cyclin-dependent kinase 5 is involved in the phosphorylation of gephyrin and clustering of GABAA receptors at inhibitory synapses of hippocampal neurons. [PDF]

PLoS ONE, 2014
CDK5 has been implicated in neural functions including growth, neuronal migration, synaptic transmission and plasticity of excitatory chemical synapses.
Heba Kalbouneh, Andrea Schlicksupp, Joachim Kirsch, Jochen Kuhse   +3 more
doaj   +1 more source

GABA_A receptors, gephyrin and homeostatic synaptic plasticity [PDF]

The Journal of Physiology, 2010
Homeostatic synaptic plasticity describes the changes in synapse gain and function that occur in response to global changes in neuronal activity to maintain the stability of neuronal networks. In this review, we argue that a coordinated regulation of excitatory and inhibitory synaptic transmission is essential for maintaining CNS function while ...
Tyagarajan, S K, Fritschy, J M
openaire   +4 more sources

The role of collybistin in gephyrin clustering at inhibitory synapses:facts and open questions

Frontiers in Cellular Neuroscience, 2011
Collybistin (Cb) is a brain-specific GDP/GTP-exchange factor, which interacts with the inhibitory receptor anchoring protein gephyrin. Data from mice carrying an inactivated Cb gene indicate that Cb is required for the formation and maintenance of ...
Theofilos ePapadopoulos, Theofilos ePapadopoulos, Tolga eSoykan   +2 more
doaj   +1 more source

Mechanism of gephyrin dependent inhibitory receptor clustering [PDF]

, 2021
Gephyrin is the major scaffolding protein at inhibitory γ-aminobutyric acid- (GABA) and glycinergic synapses. Neuronal inhibition is essential for the function of the central and peripheral nervous systems by balancing excitatory signals. The formation
Macha, Arthur
core  

Postsynaptic gephyrin clustering controls the development of adult-born granule cells in the olfactory bulb [PDF]

, 2015
In adult rodent olfactory bulb, GABAergic signaling regulates migration, differentiation, and synaptic integration of newborn granule cells (GCs), migrating from the subventricular zone.
Panzanelli, Patrizia, Pallotto, Marta, Vogt, Fabia, Tyagarajan, Shiva K, Fritschy, Jean-Marc, Deprez, Francine, Grabiec, Marta, Virtanen, Mari A, Vogt F, Virtanen MA, Tyagarajan SK, Deprez F, Grabiec M, Panzanelli P, Fritschy JM, Pallotto M   +15 more
core   +1 more source

Complementary Use of Super-Resolution Imaging Modalities to Study the Nanoscale Architecture of Inhibitory Synapses

Frontiers in Synaptic Neuroscience, 2022
The nanoscale architecture of synapses has been investigated using multiple super-resolution methods, revealing a common modular structure for scaffolds, neurotransmitter receptors, and presynaptic proteins. This fundamental organization of proteins into
Sara E. Gookin, Matthew R. Taylor, Samantha L. Schwartz, Matthew J. Kennedy, Mark L. Dell’Acqua, Kevin C. Crosby, Katharine R. Smith   +6 more
doaj   +1 more source

Phosphoinositide- and Collybistin-Dependent Synaptic Clustering of Gephyrin. [PDF]

J Neurochem
ABSTRACT Gephyrin is the main scaffolding protein at inhibitory synapses, clustering glycine and GABA A receptors. At specific GABAergic synapses, the nucleotide exchange factor collybistin recruits gephyrin to the postsynaptic membrane via interaction with phosphoinositides.
Burdina N, Liebsch F, Macha A, Gil JLO, Frommelt P, Rais I, Basler F, Pöpsel S, Schwarz G.   +8 more
europepmc   +3 more sources